SSRP1 Antibody (3E4): sc-56782
- SSRP1 Antibody (3E4) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant SSRP1 fragment of human origin
- recommended for detection of SSRP1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SSRP1 Antibody (3E4). This work is in progress.
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SSRP1 Antibody (3E4) is a mouse monoclonal IgG1 antibody that detects SSRP1 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. SSRP1 plays a crucial role in the regulation of gene expression by acting as a chromatin-specific elongation factor, essential for the transcription of chromatin templates. SSRP1 is part of the FACT complex, which is vital for the disassembly of nucleosomes during transcription, thereby facilitating the access of RNA polymerase to DNA. The interaction of SSRP1 with nucleosomes and histone H2A/H2B dimers is significant because it allows for the dynamic remodeling of chromatin, which is necessary for proper gene expression and cellular function. Additionally, SSRP1 interacts with serum response factors (SRF), serving as a positive co-regulatory protein that enhances SRF-dependent gene expression. Understanding SSRP1 function and interactions is important for elucidating the mechanisms of transcription regulation and the potential implications in various diseases where gene expression is disrupted.
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SSRP1 Antibody (3E4) References:
- SSRP1 functions as a co-activator of the transcriptional activator p63. | Zeng, SX., et al. 2002. EMBO J. 21: 5487-97. PMID: 12374749
- CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity. | Li, Y., et al. 2005. J Biol Chem. 280: 11869-75. PMID: 15659405
- Human SSRP1 has Spt16-dependent and -independent roles in gene transcription. | Li, Y., et al. 2007. J Biol Chem. 282: 6936-45. PMID: 17209051
- Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation. | Hossan, T., et al. 2016. Stem Cells. 34: 1369-76. PMID: 27146025
- SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming. | Gao, Y., et al. 2017. Cancer Res. 77: 2674-2685. PMID: 28416484
- SSRP1 silencing inhibits the proliferation and malignancy of human glioma cells via the MAPK signaling pathway. | Liao, J., et al. 2017. Oncol Rep. 38: 2667-2676. PMID: 29048646
- The SSRP1 subunit of the histone chaperone FACT is required for seed dormancy in Arabidopsis. | Michl-Holzinger, P., et al. 2019. J Plant Physiol. 236: 105-108. PMID: 30947026
- APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival. | Song, H., et al. 2021. Heliyon. 7: e06756. PMID: 33948507
- Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1. | Wang, QS., et al. 2022. Elife. 11: PMID: 36511897
- Evolution of the chromatin remodeling complex FACT: Functional analysis of SSRP1 and SPT16 in early anther development. | Zhang, Z., et al. 2025. Int J Biol Macromol. 284: 138167. PMID: 39615716
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SSRP1 Antibody (3E4) | sc-56782 | 100 µg/ml | $322.00 |