SSNA1 Antibody (C-5): sc-376254
- SSNA1 Antibody (C-5) is a mouse monoclonal IgG2a κ SSNA1 antibody provided at 200 µg/ml
- raised against amino acids 1-119 representing full length SSNA1 of human origin
- SSNA1 Antibody (C-5) is recommended for detection of SSNA1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-SSNA1 Antibody (C-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for SSNA1 Antibody (C-5) for WB and IHC(P) applications. This reagent is now offered in a bundle with SSNA1 Antibody (C-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SSNA1 Antibody (C-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects SSNA1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SSNA1 (C-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SSNA1, also known as Sjoegren syndrome nuclear autoantigen 1, N14, or NA-14, is a 119 amino acid protein predominantly located in the nucleus and cytoplasm, with highest expression levels found in testis, while lower levels are present in peripheral blood leukocytes, spleen, colon, thymus, ovary, prostate, and small intestine. SSNA1 plays a crucial role in cellular processes by interacting with microtubule structures, which are essential for maintaining cell shape, enabling intracellular transport, and facilitating cell division. An N-terminal dimeric coiled-coil domain and a C-terminal basic domain in SSNA1 suggests involvement in protein-protein interactions, potentially influencing spastin activity at the centrosome, a critical site for microtubule organization. SSNA1 is encoded on human chromosome 9, a region associated with various genetic disorders, including hereditary hemorrhagic telangiectasia and familial dysautonomia, highlighting SSNA1′s importance in both normal cellular function and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SSNA1 Antibody (C-5) References:
- Chlamydomonas DIP13 and human NA14: a new class of proteins associated with microtubule structures is involved in cell division. | Pfannenschmid, F., et al. 2003. J Cell Sci. 116: 1449-62. PMID: 12640030
- Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. | Casenghi, M., et al. 2003. Dev Cell. 5: 113-25. PMID: 12852856
- Proteomic characterization of the human centrosome by protein correlation profiling. | Andersen, JS., et al. 2003. Nature. 426: 570-4. PMID: 14654843
- Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon. | Errico, A., et al. 2004. Hum Mol Genet. 13: 2121-32. PMID: 15269182
- Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease). | Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
- Organization of the amplified type I interferon gene cluster and associated chromosome regions in the interphase nucleus of human osteosarcoma cells. | Zeitz, MJ., et al. 2009. Chromosome Res. 17: 305-19. PMID: 19283497
- Neuroimaging supports central pathology in familial dysautonomia. | Axelrod, FB., et al. 2010. J Neurol. 257: 198-206. PMID: 19705052
- NA14 is a novel nuclear autoantigen with a coiled-coil domain. | Ramos-Morales, F., et al. 1998. J Biol Chem. 273: 1634-9. PMID: 9430706
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SSNA1 Antibody (C-5) | sc-376254 | 200 µg/ml | $322.00 | |||
SSNA1 Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-522896 | 200 µg Ab, 40 µg BP | $361.00 | |||
SSNA1 Antibody (C-5) AC | sc-376254 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SSNA1 Antibody (C-5) HRP | sc-376254 HRP | 200 µg/ml | $322.00 | |||
SSNA1 Antibody (C-5) FITC | sc-376254 FITC | 200 µg/ml | $336.00 | |||
SSNA1 Antibody (C-5) PE | sc-376254 PE | 200 µg/ml | $349.00 | |||
SSNA1 Antibody (C-5) Alexa Fluor® 488 | sc-376254 AF488 | 200 µg/ml | $364.00 | |||
SSNA1 Antibody (C-5) Alexa Fluor® 546 | sc-376254 AF546 | 200 µg/ml | $364.00 | |||
SSNA1 Antibody (C-5) Alexa Fluor® 594 | sc-376254 AF594 | 200 µg/ml | $364.00 | |||
SSNA1 Antibody (C-5) Alexa Fluor® 647 | sc-376254 AF647 | 200 µg/ml | $364.00 | |||
SSNA1 Antibody (C-5) Alexa Fluor® 680 | sc-376254 AF680 | 200 µg/ml | $364.00 | |||
SSNA1 Antibody (C-5) Alexa Fluor® 790 | sc-376254 AF790 | 200 µg/ml | $364.00 |