SSH1 Antibody (1A5C8): sc-517226

SSH1 Antibody (1A5C8) is a mouse monoclonal IgG1 antibody that detects SSH1 protein of human origin by immunofluorescence (IF) and flow cytometry (FCM). Anti-SSH1 antibody (1A5C8) is available as the non-conjugated format. SSH1, also known as slingshot homolog 1, KIAA1298, or SSH1L, is a 1,049 amino acid protein that plays a crucial role in regulating actin dynamics within the cell. SSH1 (1A5C8) antibody targets a protein localized in both the cytoplasm and cytoskeleton, where SSH1 acts as a protein phosphatase, specifically dephosphorylating target proteins such as Cofilin, which is essential for the assembly and disassembly of actin filaments. This regulation is vital for various cellular processes, including cell motility, shape, and division, making SSH1 a key player in maintaining cellular architecture and function. The gene encoding SSH1 is located on human chromosome 12, which harbors over 1,100 genes and constitutes approximately 4.5% of the human genome. SSH1 is expressed in multiple alternatively spliced isoforms and undergoes post-translational modifications, including phosphorylation at specific residues like Ser 978, which can influence activity and interactions with other proteins.

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SSH1 Antibody (1A5C8) References:

1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin.  |  Niwa, R., et al. 2002. Cell. 108: 233-46. PMID: 11832213
2. Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin.  |  Endo, M., et al. 2003. J Neurosci. 23: 2527-37. PMID: 12684437
3. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.  |  Nagata-Ohashi, K., et al. 2004. J Cell Biol. 165: 465-71. PMID: 15159416
4. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.  |  Soosairajah, J., et al. 2005. EMBO J. 24: 473-86. PMID: 15660133
5. Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration.  |  Nishita, M., et al. 2005. J Cell Biol. 171: 349-59. PMID: 16230460
6. The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.  |  Kligys, K., et al. 2007. J Biol Chem. 282: 32520-8. PMID: 17848544
7. Molecular dissection of the mechanisms of substrate recognition and F-actin-mediated activation of cofilin-phosphatase Slingshot-1.  |  Kurita, S., et al. 2008. J Biol Chem. 283: 32542-52. PMID: 18809681
8. 14-3-3zeta/tau heterodimers regulate Slingshot activity in migrating keratinocytes.  |  Kligys, K., et al. 2009. Biochem Biophys Res Commun. 383: 450-4. PMID: 19371722
9. SSH1 expression is associated with gastric cancer progression and predicts a poor prognosis.  |  Maimaiti, Y., et al. 2018. BMC Gastroenterol. 18: 12. PMID: 29338701
10. Role of SSH1 in colorectal cancer prognosis and tumor progression.  |  Song, X., et al. 2020. J Gastroenterol Hepatol. 35: 1180-1188. PMID: 32020663
11. SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation.  |  Fang, C., et al. 2021. Autophagy. 17: 2144-2165. PMID: 33044112
12. SSH1 promotes progression of intrahepatic cholangiocarcinoma via p38 MAPK-CXCL8 axis.  |  Chen, F., et al. 2023. Carcinogenesis. 44: 232-241. PMID: 36857607

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SSH1 Antibody (1A5C8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SSH1 Antibody (1A5C8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SSH1 Antibody (1A5C8) Specifications

Alternate Product Name: SSH1

Product Clone Name: 1A5C8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 1032-1044

Epitope Target: SSH1

Epitope Species: human

Product Reactivity/Detection: SSH1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SSH1 Antibody (1A5C8): N/A