SSBP2 Antibody (D-3): sc-166687

SSBP2 Antibody (D-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects SSBP2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SSBP2 (D-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SSBP2, also known as single-stranded DNA binding protein 2 or SSDP2, is a crucial 361 amino acid protein that plays a significant role in DNA metabolism by binding to single-stranded DNA, thereby protecting DNA from degradation and facilitating proper DNA replication and repair processes. SSBP2 is predominantly localized in the nucleus, where SSBP2′s presence is vital for maintaining genomic stability and regulating cell cycle progression. SSBP2 is expressed in various tissues, and SSBP2′s function as a potential tumor suppressor is underscored by SSBP2′s ability to induce growth arrest in cancer cells, making SSBP2 an important target for cancer research. The gene encoding SSBP2 is located on human chromosome 5, a region associated with several genetic disorders, including Cockayne syndrome and familial adenomatous polyposis, highlighting SSBP2′s clinical relevance in understanding disease mechanisms.

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SSBP2 Antibody (D-3) References:

1. A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity.  |  Castro, P., et al. 2002. Genomics. 80: 78-85. PMID: 12079286
2. SSBP2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid leukemia cells.  |  Liang, H., et al. 2005. Oncogene. 24: 2625-34. PMID: 15782145
3. Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins.  |  Xu, Z., et al. 2007. Genes Dev. 21: 942-55. PMID: 17437998
4. ssDNA-binding protein 2 is frequently hypermethylated and suppresses cell growth in human prostate cancer.  |  Liu, JW., et al. 2008. Clin Cancer Res. 14: 3754-60. PMID: 18559593
5. Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia.  |  Poitras, JL., et al. 2008. Genes Chromosomes Cancer. 47: 884-9. PMID: 18618714
6. SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability.  |  Wang, Y., et al. 2010. Oncogene. 29: 3044-53. PMID: 20348955
7. SSBP2 variants are associated with survival in glioblastoma patients.  |  Xiao, Y., et al. 2012. Clin Cancer Res. 18: 3154-62. PMID: 22472174
8. Requirement for ssbp2 in hematopoietic stem cell maintenance and stress response.  |  Li, J., et al. 2014. J Immunol. 193: 4654-62. PMID: 25238756
9. SSBP2-CSF1R is a recurrent fusion in B-lineage acute lymphoblastic leukemia with diverse genetic presentation and variable outcome.  |  Schwab, C., et al. 2021. Blood. 137: 1835-1838. PMID: 33197935
10. Nuclear Expression Loss of SSBP2 Is Associated with Poor Prognostic Factors in Colorectal Adenocarcinoma.  |  Chung, Y., et al. 2020. Diagnostics (Basel). 10: PMID: 33339271
11. GWAS in Mice Maps Susceptibility to HIV-Associated Nephropathy to the Ssbp2 Locus.  |  Steers, NJ., et al. 2022. J Am Soc Nephrol. 33: 108-120. PMID: 34893534
12. Cloning and characterization of a novel sequence-specific single-stranded-DNA-binding protein.  |  Bayarsaihan, D., et al. 1998. Biochem J. 331 (Pt 2): 447-52. PMID: 9531483

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SSBP2 Antibody (D-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SSBP2 Antibody (D-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SSBP2 Antibody (D-3) Specifications

Alternate Product Name: SSBP2

Product Clone Name: D-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 311-355

Epitope Target: SSBP2

Epitope Species: human

Product Reactivity/Detection: SSBP2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SSBP2 Antibody (D-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin