ss/ds DNA marker Antibody (8.F.76): sc-73060
- ss/ds DNA marker Antibody (8.F.76) is a mouse monoclonal IgM provided at 100 µg/ml
- raised against calf thymus DNA
- recommended for detection of single or double stranded eukaryotic DNA of mammalian origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ss/ds DNA marker Antibody (8.F.76). This work is in progress.
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ss/ds DNA marker Antibody (8.F.76) is a mouse monoclonal IgM antibody that detects deoxyribonucleic acid (DNA) in mammalian species through western blotting (WB). Anti-DNA antibody (8.F.76) plays a crucial role in distinguishing between single-stranded and double-stranded DNA, which is essential for various molecular biology applications, including the study of DNA replication, repair, and transcription. DNA monoclonal antibody (8.F.76) enables differentiation between these two forms of DNA, as single-stranded DNA serves as an intermediate during processes like replication and transcription, while double-stranded DNA represents the stable, functional form of genetic material. Understanding the dynamics between these two states can provide insights into cellular processes and mechanisms of diseases, including cancer, where DNA damage and repair pathways are frequently disrupted. DNA (8.F.76) antibody effectively analyzes the presence and state of DNA in samples, facilitating advancements in genetic research and therapeutic development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ss/ds DNA marker Antibody (8.F.76) References:
- Single-stranded DNA aptamers that bind differentiated but not parental cells: subtractive systematic evolution of ligands by exponential enrichment. | Wang, C., et al. 2003. J Biotechnol. 102: 15-22. PMID: 12668310
- DNA aptamers that bind to MUC1 tumour marker: design and characterization of MUC1-binding single-stranded DNA aptamers. | Ferreira, CS., et al. 2006. Tumour Biol. 27: 289-301. PMID: 17033199
- Oligo(dT) is not a correct native PAGE marker for single-stranded DNA. | Kejnovská, I., et al. 2007. Biochem Biophys Res Commun. 353: 776-9. PMID: 17196168
- Photothermal release of single-stranded DNA from the surface of gold nanoparticles through controlled denaturating and Au-S bond breaking. | Poon, L., et al. 2010. ACS Nano. 4: 6395-403. PMID: 20958080
- Electrochemical DNA biosensors for label-free breast cancer gene marker detection. | Senel, M., et al. 2019. Anal Bioanal Chem. 411: 2925-2935. PMID: 30957202
- DIRS retrotransposons amplify via linear, single-stranded cDNA intermediates. | Malicki, M., et al. 2020. Nucleic Acids Res. 48: 4230-4243. PMID: 32170321
- Comparison of mutagenesis induced in single- and double-stranded M13 viral DNA by treatment with N-hydroxy-2-aminofluorene. | Gupta, PK., et al. 1988. Carcinogenesis. 9: 1337-45. PMID: 3402029
- Detection of antibodies to single-stranded DNA in naturally acquired and experimentally induced viral hepatitis. | Gust, ID., et al. 1980. J Med Virol. 6: 1-10. PMID: 7229624
- DNA single-strand breaks and toxicity induced by 4-(methyl-nitrosamino)-1-(3- pyridyl)-1-butanone or N-nitrosodimethylamine in hamster and rat liver. | Jorquera, R., et al. 1994. Carcinogenesis. 15: 389-94. PMID: 8313533
- Single stranded DNA as an immunocytochemical marker for apoptotic change of ischemia in the gerbil hippocampus. | Maeda, M., et al. 1998. Neurosci Lett. 240: 69-72. PMID: 9486474
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ss/ds DNA marker Antibody (8.F.76) | sc-73060 | 100 µg/ml | $322.00 |