SRp20 Antibody (3G271): sc-73059

SRp20 Antibody (3G271) is a mouse monoclonal IgG1 antibody that detects SRp20 in mouse, rat, human, and avian species through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SRp20 is a crucial member of the serine/arginine-rich (SR) protein family, which plays a significant role in the regulation of pre-mRNA splicing. SRp20 is primarily located in the nucleus, where SRp20 is essential for the recognition of splice sites and the control of alternative splicing, processes that are vital for generating diverse protein isoforms from a single gene. The nuclear localization of SRp20 allows interaction with other splicing factors and RNA, facilitating the assembly of the spliceosome, the molecular machinery responsible for splicing. Additionally, SRp20 shuttles between the nucleus and cytoplasm, contributing to mRNA transport, which is critical for gene expression regulation. The proper functioning of SRp20 is essential for maintaining cellular homeostasis, as dysregulation of splicing can lead to various diseases, including cancer. With its ability to enhance splice site recognition and influence alternative splicing, anti-SRp20 antibody (3G271) is an invaluable tool for researchers studying the complexities of gene expression and splicing mechanisms.

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SRp20 Antibody (3G271) References:

1. Regulation of SRp20 exon 4 splicing.  |  Jumaa, H. and Nielsen, PJ. 2000. Biochim Biophys Acta. 1494: 137-43. PMID: 11072076
2. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA.  |  Huang, Y. and Steitz, JA. 2001. Mol Cell. 7: 899-905. PMID: 11336712
3. Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.  |  Hargous, Y., et al. 2006. EMBO J. 25: 5126-37. PMID: 17036044
4. Control of the papillomavirus early-to-late switch by differentially expressed SRp20.  |  Jia, R., et al. 2009. J Virol. 83: 167-80. PMID: 18945760
5. SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAs.  |  Escudero-Paunetto, L., et al. 2010. Virology. 401: 155-64. PMID: 20227104
6. Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus.  |  Fitzgerald, KD. and Semler, BL. 2011. PLoS Pathog. 7: e1002127. PMID: 21779168
7. Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease.  |  Wong, J., et al. 2012. J Neurochem. 123: 159-71. PMID: 22788679
8. Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections.  |  Fitzgerald, KD., et al. 2013. J Virol. 87: 2390-400. PMID: 23255796
9. Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis.  |  Zhu, S., et al. 2016. Oncogene. 35: 1847-56. PMID: 26119931
10. Human Papillomavirus E2 Regulates SRSF3 (SRp20) To Promote Capsid Protein Expression in Infected Differentiated Keratinocytes.  |  Klymenko, T., et al. 2016. J Virol. 90: 5047-58. PMID: 26962216

The preferred SR antibody is SR Antibody (1H4): sc-13509.