SRP14 Antibody (B-3): sc-377012

SRP14 Antibody (B-3) is a mouse monoclonal IgG3 kappa light chain antibody that detects SRP14 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SRP14 (B-3) antibody is available as the non-conjugated form. SRP14 plays a critical role in signal recognition particle (SRP) function, which is essential for proper targeting of nascent proteins to the endoplasmic reticulum. This targeting is vital for translocation of proteins destined for secretion or incorporation into the cell membrane, thereby influencing cellular function and homeostasis. SRP complex, including SRP14, is composed of RNA and protein components, and its integrity is crucial for efficient recognition and binding of ribosome-nascent chain complexes. Disruption of SRP function can lead to protein mislocalization, which may contribute to various diseases, including cancer and neurodegenerative disorders. SRP14′s interaction with SRP9 is particularly important, as this heterodimer stabilizes SRP RNA structure, facilitating its role in protein targeting.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SRP14 Antibody (B-3) References:

1. Structure and assembly of the Alu domain of the mammalian signal recognition particle.  |  Weichenrieder, O., et al. 2000. Nature. 408: 167-73. PMID: 11089964
2. Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9.  |  Hsu, K., et al. 1995. J Biol Chem. 270: 10179-86. PMID: 7730321
3. A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA.  |  Chang, DY., et al. 1994. Mol Cell Biol. 14: 3949-59. PMID: 8196634
4. The Signal Recognition Particle Database (SRPDB).  |  Larsen, N., et al. 1998. Nucleic Acids Res. 26: 177-8. PMID: 9399828

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SRP14 Antibody (B-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SRP14 Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SRP14 Antibody (B-3) Specifications

Alternate Product Name: SRP14

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 35-73

Epitope Target: SRP14

Epitope Species: human

Product Reactivity/Detection: SRP14

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SRP14 Antibody (B-3): P: Blocking Peptide