SRC-1 Antibody (8): sc-136077

SRC-1 Antibody (8) is a mouse monoclonal IgG2a antibody that detects SRC-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SRC-1, also known as steroid receptor coactivator-1, plays a crucial role in the regulation of gene expression by acting as a coactivator for steroid hormone receptors, thereby enhancing transcriptional activity. SRC-1 is primarily located in the nucleus, where SRC-1 interacts with various transcription factors and chromatin remodeling complexes to facilitate the transcription of hormone-responsive genes. SRC-1′s nuclear localization enables modulation of genes involved in critical biological processes, including metabolism, reproduction, and cell growth. Additionally, SRC-1 undergoes post-translational modifications, such as phosphorylation, which can influence activity and stability, further underscoring SRC-1′s significance in cellular signaling pathways. Anti-SRC-1 antibody (8) is an essential tool for researchers studying the intricate mechanisms of hormone signaling and gene regulation.

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SRC-1 Antibody (8) References:

1. Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.  |  Liu, Z., et al. 1999. Proc Natl Acad Sci U S A. 96: 9485-90. PMID: 10449719
2. Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor.  |  Han, SJ., et al. 2006. Mol Endocrinol. 20: 45-55. PMID: 16141356
3. PIASy inhibits LRH-1-dependent CYP11A1 expression by competing for SRC-1 binding.  |  Hsieh, HT., et al. 2009. Biochem J. 419: 201-9. PMID: 19067654
4. Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines.  |  Hernández-Hernández, OT., et al. 2010. Endocrine. 37: 194-200. PMID: 20963570
5. The coactivator SRC-1 is an essential coordinator of hepatic glucose production.  |  Louet, JF., et al. 2010. Cell Metab. 12: 606-18. PMID: 21109193
6. Cutting SRC-1 down to size in endometriosis.  |  Dyson, MT. and Bulun, SE. 2012. Nat Med. 18: 1016-8. PMID: 22772552
7. Global gene repression by the steroid receptor coactivator SRC-1 promotes oncogenesis.  |  Walsh, CA., et al. 2014. Cancer Res. 74: 2533-44. PMID: 24648347
8. SRC-1 and Twist1 expression positively correlates with a poor prognosis in human breast cancer.  |  Xu, Y., et al. 2014. Int J Biol Sci. 10: 396-403. PMID: 24719557
9. Extracellular Vesicle Activation of Latent HIV-1 Is Driven by EV-Associated c-Src and Cellular SRC-1 via the PI3K/AKT/mTOR Pathway.  |  Barclay, RA., et al. 2020. Viruses. 12: PMID: 32575590
10. The Src1-PGC1α-AP1 complex-dependent secretion of substance P induces inflammation and apoptosis in encephalomyocarditis virus-infected mice.  |  Chen, FX., et al. 2023. Cytokine. 165: 156186. PMID: 36989655

The preferred SRC-1 antibody is SRC-1 Antibody (1135/H4): sc-32789.