SR-4 Antibody (G-3): sc-376158

SR-4 Antibody (G-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects SR-4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SR-4 (G-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SR-4 protein, also known as 5-Hydroxytryptamine Receptor 4, plays a crucial role in mediating serotonin′s effects throughout the central and peripheral nervous systems, influencing physiological processes such as mood regulation, gastrointestinal motility, and cardiovascular function. SR-4 is primarily located in the brain and gastrointestinal tract, where SR-4 facilitates communication between neurons and regulates various neurotransmitter systems. Proper functioning of SR-4 is essential for maintaining homeostasis, as dysregulation of serotonin signaling has been implicated in numerous psychiatric and gastrointestinal disorders. SR-4 gene is located on human chromosome 5q31-q33, and SR-4 interactions with other serotonin receptors and signaling pathways underscore SR-4′s importance in both health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SR-4 Antibody (G-3) References:

1. Serotonin 2B receptor is required for heart development.  |  Nebigil, CG., et al. 2000. Proc Natl Acad Sci U S A. 97: 9508-13. PMID: 10944220
2. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice.  |  Gingrich, JA. and Hen, R. 2001. Psychopharmacology (Berl). 155: 1-10. PMID: 11374326
3. Definition of pharmacological receptors.  |  Kenakin, TP., et al. 1992. Pharmacol Rev. 44: 351-62. PMID: 1438521
4. Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.  |  Maricq, AV., et al. 1991. Science. 254: 432-7. PMID: 1718042
5. Effect of 5-hydroxytryptamine receptor 4 agonist mosapride on human gastric accommodation.  |  Amano, T., et al. 2015. Neurogastroenterol Motil. 27: 1303-9. PMID: 26303048
6. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome.  |  Gelernter, J., et al. 1995. Genomics. 26: 207-9. PMID: 7601444
7. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.  |  Ruat, M., et al. 1993. Proc Natl Acad Sci U S A. 90: 8547-51. PMID: 8397408
8. Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2.  |  Weiss, B., et al. 1995. Genomics. 29: 304-5. PMID: 8530095
9. Central 5-HT4 receptors.  |  Eglen, RM., et al. 1995. Trends Pharmacol Sci. 16: 391-8. PMID: 8578609
10. Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31-->q33 by in situ hybridization.  |  Claeysen, S., et al. 1997. Cytogenet Cell Genet. 78: 133-4. PMID: 9371406
11. Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors.  |  Goppelt-Struebe, M. and Stroebel, M. 1998. J Cell Physiol. 175: 341-7. PMID: 9572479
12. The 5-HT3B subunit is a major determinant of serotonin-receptor function.  |  Davies, PA., et al. 1999. Nature. 397: 359-63. PMID: 9950429

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SR-4 Antibody (G-3) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-SR-4 Antibody (G-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SR-4 Antibody (G-3) Specifications

Alternate Product Name: HTR4

Product Clone Name: G-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 156-284

Epitope Target: SR-4

Epitope Species: human

Product Reactivity/Detection: SR-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for SR-4 Antibody (G-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin