SPIN90 Antibody (B-6): sc-514232

SPIN90 Antibody (B-6) is a mouse monoclonal IgM antibody that detects SPIN90 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SPIN90 antibody (B-6) is available as the non-conjugated form. SPIN90, also known as NCK-interacting protein with SH3 domain or diaphanous protein-interacting protein (DIP-1), is a 722 amino acid protein encoded by the human gene SPIN90. SPIN90 is primarily located in the nucleus and contains an SH3 domain, a proline-rich domain, and a bipartite nuclear localization signal, which are crucial for cellular processes. Nuclear localization of SPIN90 enables interaction with various nuclear factors, influencing gene expression and cellular signaling pathways. SPIN90 plays a vital role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1) and participates in myofibril assembly into sarcomeres, essential for muscle contraction. SPIN90 regulates actin polymerization and cell adhesion, maintaining cellular structure and function. A chromosomal aberration involving SPIN90/AF3p21 has been identified in therapy-related leukemia, suggesting a potential role in oncogenesis. MLL gene, frequently rearranged in leukemia, is located at chromosome 11q23 and participates in various chromosomal translocations, particularly in infantile and therapy-related leukemia, highlighting SPIN90′s significance in normal cellular function and disease states.

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SPIN90 Antibody (B-6) References:

1. Structure of AF3p21, a new member of mixed lineage leukemia (MLL) fusion partner proteins-implication for MLL-induced leukemogenesis.  |  Sano, K. 2001. Leuk Lymphoma. 42: 595-602. PMID: 11697487
2. Interaction of SPIN90 with dynamin I and its participation in synaptic vesicle endocytosis.  |  Kim, Y., et al. 2005. J Neurosci. 25: 9515-23. PMID: 16221862
3. A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.  |  García, A., et al. 2006. Proteomics. 6: 5332-43. PMID: 16941570
4. SPIN90/WISH interacts with PSD-95 and regulates dendritic spinogenesis via an N-WASP-independent mechanism.  |  Lee, S., et al. 2006. EMBO J. 25: 4983-95. PMID: 16990791
5. Interaction of SPIN90 with syndapin is implicated in clathrin-mediated endocytic pathway in fibroblasts.  |  Kim, SH., et al. 2006. Genes Cells. 11: 1197-211. PMID: 16999739
6. Ever-expanding network of dynamin-interacting proteins.  |  Kim, Y. and Chang, S. 2006. Mol Neurobiol. 34: 129-36. PMID: 17220534
7. F-actin binding region of SPIN90 C-terminus is essential for actin polymerization and lamellipodia formation.  |  Kim, DJ., et al. 2007. Cell Commun Adhes. 14: 33-43. PMID: 17453829

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SPIN90 Antibody (B-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SPIN90 Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SPIN90 Antibody (B-6) Specifications

Alternate Product Name: SPIN90

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 43-65

Epitope Target: SPIN90

Epitope Species: human

Product Reactivity/Detection: SPIN90

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SPIN90 Antibody (B-6): P: Blocking Peptide