SPIN90 Antibody (2614C1a): sc-81383
- SPIN90 Antibody (2614C1a) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of SPIN90 of human origin
- recommended for detection of SPIN90 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SPIN90 Antibody (2614C1a). This work is in progress.
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SEE ALSO...
SPIN90 Antibody (2614C1a) is a mouse monoclonal IgG1 antibody that detects SPIN90 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. SPIN90, also known as NCK-interacting protein with SH3 domain or diaphanous protein-interacting protein, is a 722 amino acid nuclear protein that plays a crucial role in cellular architecture and dynamics. SPIN90 contains an SH3 domain, a proline-rich domain, and a bipartite nuclear localization signal, with the SH3 domain exhibiting high homology to that of FYN. SPIN90 is essential for the formation of stress fibers induced by active diaphanous protein homolog 1 (DRF1) and is involved in the assembly of myofibrils into sarcomeres, which are vital for muscle contraction and structural integrity. Additionally, SPIN90 is implicated in regulating actin polymerization and cell adhesion, processes that are critical for maintaining cellular shape and facilitating communication between cells. Notably, chromosomal aberrations involving SPIN90, particularly the MLL-AF3p21 fusion transcript, have been associated with therapy-related leukemia, highlighting SPIN90′s significance in both normal cellular function and disease states. Anti-SPIN90 antibody (2614C1a) effectively targets SPIN90, making this antibody a valuable tool for researchers studying its role in cellular processes and implications in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SPIN90 Antibody (2614C1a) | sc-81383 | 100 µg/ml | $339.00 |