SPATA33 Antibody (D-3): sc-514707

SPATA33 Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects SPATA33 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SPATA33, also known as C16orf55, is a 133 amino acid protein that plays a vital role in sperm motility and male fertility, making SPATA33 essential for reproductive health. SPATA33 is crucial for providing the sperm midpiece with necessary flexibility and ensuring correct localization of sperm calcineurin within mitochondria, as evidenced by comparative studies. Notably, SPATA33 promotes mitophagy and acts as an autophagy mediator specifically within male germline cells, facilitating the connection of damaged mitochondria to autophagosomes by interacting with outer mitochondrial membrane protein VDAC2 and central autophagy component ATG16L1. The gene encoding SPATA33 is located on human chromosome 16q24.3 and exists as two alternatively spliced isoforms, highlighting SPATA33′s complexity and potential regulatory mechanisms. Anti-SPATA33 antibody (D-3) is an invaluable tool for researchers investigating molecular pathways of male fertility and mitochondrial dynamics.

The preferred SPATA33 antibody is SPATA33 Antibody (A-2): sc-514699.