SPATA33 Antibody (A-2): sc-514699

SPATA33 Antibody (A-2) is a mouse monoclonal IgG3 kappa light chain antibody that detects SPATA33 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SPATA33 antibody (A-2) is available as a non-conjugated format. SPATA33, also known as spermatogenesis-associated protein 33 or C16orf55, is a 133 amino acid protein that plays a vital role in sperm motility and male fertility. SPATA33 is primarily located in the mitochondria of sperm cells, where SPATA33 is crucial for maintaining mitochondrial function and integrity. This localization is significant because mitochondria are responsible for producing the energy required for sperm movement, and any dysfunction can lead to impaired motility and fertility issues. SPATA33 is essential for proper placement of sperm calcineurin within mitochondria, which is necessary for effective mitochondrial dynamics. Additionally, SPATA33 facilitates mitophagy, the process of removing damaged mitochondria, by interacting with outer mitochondrial membrane protein VDAC2 and central autophagy component ATG16L1, thereby ensuring health and functionality of sperm cells. The gene encoding SPATA33 is located on human chromosome 16q24.3 and exists as two alternatively spliced isoforms, highlighting complexity and potential regulatory mechanisms in spermatogenesis.

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SPATA33 Antibody (A-2) References:

1. Homozygosity mapping of giant axonal neuropathy gene to chromosome 16q24.1.  |  Ben Hamida, C., et al. 1997. Neurogenetics. 1: 129-33. PMID: 10732815
2. Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations.  |  Karlsson, J., et al. 2003. J Immunol. 170: 1019-26. PMID: 12517969
3. Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus.  |  Forabosco, P., et al. 2006. Genes Immun. 7: 609-14. PMID: 16971955
4. Giant axonal neuropathy.  |  Yang, Y., et al. 2007. Cell Mol Life Sci. 64: 601-9. PMID: 17256086
5. Genotype-phenotype analysis in patients with giant axonal neuropathy (GAN).  |  Koop, O., et al. 2007. Neuromuscul Disord. 17: 624-30. PMID: 17587580
6. The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation.  |  Tattoli, I., et al. 2007. Semin Immunopathol. 29: 289-301. PMID: 17690884
7. Identification, evolution, and association study of a novel promoter and first exon of the human NOD2 (CARD15) gene.  |  King, K., et al. 2007. Genomics. 90: 493-501. PMID: 17719742
8. High frequency of mosaic CREBBP deletions in Rubinstein-Taybi syndrome patients and mapping of somatic and germ-line breakpoints.  |  Gervasini, C., et al. 2007. Genomics. 90: 567-73. PMID: 17855048
9. Nod-like receptors in innate immunity and inflammatory diseases.  |  Carneiro, LA., et al. 2007. Ann Med. 39: 581-93. PMID: 18038361

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SPATA33 Antibody (A-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SPATA33 Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SPATA33 Antibody (A-2) Specifications

Alternate Product Name: SPATA33

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1-19

Epitope Target: SPATA33

Epitope Species: human

Product Reactivity/Detection: SPATA33

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SPATA33 Antibody (A-2): P: Blocking Peptide