Sox2 Antibody (D-9): sc-398254

Sox-2 Antibody (D-9) is a mouse monoclonal IgM kappa light chain antibody designed to detect human Sox-2 protein with exceptional precision across multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Sox-2 monoclonal antibody (D-9) targets a meticulously mapped epitope within amino acids 267-291 near the C-terminus of human Sox-2, ensuring strong and reliable binding. Sox-2 (D-9) antibody exhibits broad species reactivity, effectively recognizing Sox-2 from mouse, rat, and human origins, as well as other species such as equine, canine, bovine, porcine, and avian, making Sox-2 (D-9) monoclonal antibody a versatile tool for diverse research needs. Sox-2 is a critical member of the SRY-related HMG-box (Sox) family of transcription factors, characterized by the presence of a High-Mobility Group (HMG) domain that facilitates sequence-specific DNA binding and induces conformational changes in DNA structure. Sox-2 undergoes various post-translational modifications, including phosphorylation, acetylation, and ubiquitination, which are essential for regulating stability, subcellular localization, and transcriptional activity. These modifications enable Sox-2 to respond dynamically to cellular signals, thereby modulating gene expression programs that maintain pluripotency and drive differentiation in embryonic stem cells. Dysregulation of Sox-2 post-translational modifications has been implicated in numerous developmental disorders and cancers, highlighting the importance of studying these modifications to understand disease mechanisms and identify potential therapeutic targets. Anti-Sox-2 antibody (D-9) is recommended for researchers studying expression patterns and functional roles of Sox-2 and the impact of post-translational modifications, thereby advancing insights into developmental biology, regenerative medicine, and disease pathology. Sox-2 (D-9) monoclonal antibody is available in a non-conjugated form, providing flexibility for various experimental setups.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sox2 Antibody (D-9) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Sox2 Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sox2 Antibody (D-9) Specifications

Alternate Product Name: SOX2

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 267-291

Epitope Target: Sox-2

Epitope Species: human

Product Reactivity/Detection: Sox-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Sox2 Antibody (D-9): P: Blocking Peptide, X: TransCruz Reagent

The preferred Sox2 antibody is Sox2 Antibody (E-4): sc-365823.