Sox-17 Antibody (3.5CH): sc-130295

Sox-17 Antibody (3.5CH) is a mouse monoclonal IgG1 kappa light chain antibody that detects Sox-17 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Sox-17 (3.5CH) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sox-17 plays a crucial role in regulating gene expression during embryonic development, particularly in endoderm formation and pancreas and liver development. Sox-17′s ability to bind specific DNA sequences enables function as a transcription factor, influencing stem cell fate and differentiation into various cell types. Proper Sox-17 function is essential for normal development, and dysregulation has been implicated in various developmental disorders and diseases, including certain types of cancer. Understanding Sox-17′s role in these processes is vital for advancing therapeutic strategies and improving developmental biology knowledge.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Sox-17 Antibody (3.5CH) References:

1. Identification of a novel Sry-related gene and its germ cell-specific expression.  |  Osaki, E., et al. 1999. Nucleic Acids Res. 27: 2503-10. PMID: 10359848
2. Roles of Sox factors in neural determination: conserved signaling in evolution?  |  Sasai, Y. 2001. Int J Dev Biol. 45: 321-6. PMID: 11291862
3. SOX17 is a critical specifier of human primordial germ cell fate.  |  Irie, N., et al. 2015. Cell. 160: 253-68. PMID: 25543152
4. Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via HGF/c-Met Signaling.  |  Park, CS., et al. 2022. Circ Res. 131: 792-806. PMID: 36205124
5. SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics.  |  Sangam, S., et al. 2023. Am J Respir Crit Care Med. 207: 1055-1069. PMID: 36913491
6. SOX17 is a Critical Factor in Maintaining Endothelial Function in Pulmonary Hypertension by an Exosome-Mediated Autocrine Manner.  |  Zou, X., et al. 2023. Adv Sci (Weinh). 10: e2206139. PMID: 36919784
7. SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.  |  Walters, R., et al. 2023. Circulation. 147: 1606-1621. PMID: 37066790
8. E2F1 Mediates SOX17 Deficiency-Induced Pulmonary Hypertension.  |  Yi, D., et al. 2023. Hypertension. 80: 2357-2371. PMID: 37737027
9. SOX17 enables immune evasion of early colorectal adenomas and cancers.  |  Goto, N., et al. 2024. Nature. 627: 636-645. PMID: 38418875
10. Ancestry and diversity of the HMG box superfamily.  |  Laudet, V., et al. 1993. Nucleic Acids Res. 21: 2493-501. PMID: 8506143
11. Sox10, a novel transcriptional modulator in glial cells.  |  Kuhlbrodt, K., et al. 1998. J Neurosci. 18: 237-50. PMID: 9412504
12. Characterisation and mapping of the human SOX14 gene.  |  Arsic, N., et al. 1998. Cytogenet Cell Genet. 83: 139-46. PMID: 9925951

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sox-17 Antibody (3.5CH) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-Sox-17 Antibody (3.5CH) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sox-17 Antibody (3.5CH) Specifications

Alternate Product Name: SOX17

Product Clone Name: 3.5CH

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Sox-17

Epitope Species: mouse

Product Reactivity/Detection: Sox-17

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for Sox-17 Antibody (3.5CH): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin