Sos 1 Antibody (A-9): sc-17793

Sos 1 Antibody (A-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects Sos 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sos 1 (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sos 1 protein plays a crucial role as a guanine nucleotide exchange factor (GEF) that activates Ras proteins, which are pivotal in regulating cell growth, differentiation, and survival. By facilitating the exchange of GDP for GTP on Ras, Sos 1 initiates a signaling cascade that leads to the activation of downstream effectors, including the MAP kinase pathway, which is essential for various cellular responses. Proper functioning of Sos 1 is vital, as dysregulation of Ras signaling is implicated in numerous cancers and other diseases. Additionally, Sos 1 interacts with other proteins, such as Grb2, which serves as an adapter that links receptor tyrosine kinases to the Ras signaling pathway, further emphasizing the importance of Sos 1 in cellular signaling networks.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Sos 1 Antibody (A-9) References:

1. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.  |  Lowenstein, EJ., et al. 1992. Cell. 70: 431-42. PMID: 1322798
2. The function of GRB2 in linking the insulin receptor to Ras signaling pathways.  |  Skolnik, EY., et al. 1993. Science. 260: 1953-5. PMID: 8316835
3. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1.  |  Zhang, XF., et al. 1993. Nature. 364: 308-13. PMID: 8332187
4. An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro.  |  Simon, MA., et al. 1993. Cell. 73: 169-77. PMID: 8462097
5. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.  |  Egan, SE., et al. 1993. Nature. 363: 45-51. PMID: 8479536
6. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor.  |  Buday, L. and Downward, J. 1993. Cell. 73: 611-20. PMID: 8490966
7. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.  |  Chardin, P., et al. 1993. Science. 260: 1338-43. PMID: 8493579

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sos 1 Antibody (A-9) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-Sos 1 Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sos 1 Antibody (A-9) Specifications

Alternate Product Name: SOS1

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1057-1178

Epitope Target: Sos 1

Epitope Species: human

Product Reactivity/Detection: Sos 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for Sos 1 Antibody (A-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin