SorLA Antibody (7D7B11): sc-101426
- SorLA Antibody (7D7B11) is a mouse monoclonal IgG1 SorLA antibody provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 2159-2214 of SorLA of human origin
- SorLA Antibody (7D7B11) is recommended for detection of SorLA of human origin by WB, IP and ELISA
- Anti-SorLA Antibody (7D7B11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SorLA Antibody (7D7B11). This work is in progress.
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SorLA Antibody (7D7B11) is a mouse monoclonal IgG1 antibody that detects the SorLA protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). SorLA (7D7B11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SorLA, also known as Sortilin-related receptor containing LDLR class A, is a Type I membrane protein that plays a crucial role in cellular processes, particularly in the uptake of lipoproteins and proteases. SorLA functions as a multifunctional endocytic receptor, facilitating the transport of low-density lipoprotein (LDL) into cells through endocytosis, which is vital for maintaining cholesterol homeostasis and cellular signaling. SorLA is synthesized as a proreceptor and undergoes processing by furin-like propeptidases to achieve its mature form. SorLA interacts with receptor-associated protein (RAP) and binds neuropeptides such as head activator, which are important for signaling pathways in the brain. SorLA is predominantly expressed in the brain, particularly in regions such as the cerebral cortex, cerebellum, and occipital pole, but is also found in other tissues including the liver, spinal cord, kidney, testis, and pancreas, highlighting diverse functional roles across different biological systems.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SorLA Antibody (7D7B11) References:
- Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. | Nielsen, MS., et al. 1999. J Biol Chem. 274: 8832-6. PMID: 10085125
- Characterization of the VPS10 domain of SorLA/LR11 as binding site for the neuropeptide HA. | Lintzel, J., et al. 2002. Biol Chem. 383: 1727-33. PMID: 12530537
- Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase. | Rogawski, DS., et al. 2015. Biochemistry. 54: 5401-13. PMID: 26292256
- ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. | Zhu, L., et al. 2016. Cancer Discov. 6: 770-83. PMID: 27154821
- ASH1L histone methyltransferase regulates the handoff between damage recognition factors in global-genome nucleotide excision repair. | Balbo Pogliano, C., et al. 2017. Nat Commun. 8: 1333. PMID: 29109511
- The Trithorax protein Ash1L promotes myoblast fusion by activating Cdon expression. | Castiglioni, I., et al. 2018. Nat Commun. 9: 5026. PMID: 30487570
- Structural and functional specificity of H3K36 methylation. | Lam, UTF., et al. 2022. Epigenetics Chromatin. 15: 17. PMID: 35581654
- PHD-BAH Domain in ASH1L Could Recognize H3K4 Methylation and Regulate the Malignant Behavior of Cholangiocarcinoma. | Zhang, XY. and Li, Y. 2024. Anticancer Agents Med Chem. 24: 1264-1274. PMID: 39034728
- Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors. | Huang, G., et al. 2025. J Med Chem. 68: 174-195. PMID: 39680643
- Has_circ_ASH1L acts as a sponge for miR-1254 to promote the malignant progression of cervical cancer by targeting CD36. | Zhang, J., et al. 2025. Cancer Gene Ther.. PMID: 39748122
- Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. | Jacobsen, L., et al. 1996. J Biol Chem. 271: 31379-83. PMID: 8940146
- A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens. | Mörwald, S., et al. 1997. Arterioscler Thromb Vasc Biol. 17: 996-1002. PMID: 9157966
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SorLA Antibody (7D7B11) | sc-101426 | 200 µg/ml | $322.00 | |||
SorLA Antibody (7D7B11) AC | sc-101426 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SorLA Antibody (7D7B11) HRP | sc-101426 HRP | 200 µg/ml | $322.00 | |||
SorLA Antibody (7D7B11) FITC | sc-101426 FITC | 200 µg/ml | $336.00 | |||
SorLA Antibody (7D7B11) PE | sc-101426 PE | 200 µg/ml | $349.00 | |||
SorLA Antibody (7D7B11) Alexa Fluor® 488 | sc-101426 AF488 | 200 µg/ml | $364.00 | |||
SorLA Antibody (7D7B11) Alexa Fluor® 546 | sc-101426 AF546 | 200 µg/ml | $364.00 | |||
SorLA Antibody (7D7B11) Alexa Fluor® 594 | sc-101426 AF594 | 200 µg/ml | $364.00 | |||
SorLA Antibody (7D7B11) Alexa Fluor® 647 | sc-101426 AF647 | 200 µg/ml | $364.00 | |||
SorLA Antibody (7D7B11) Alexa Fluor® 680 | sc-101426 AF680 | 200 µg/ml | $364.00 | |||
SorLA Antibody (7D7B11) Alexa Fluor® 790 | sc-101426 AF790 | 200 µg/ml | $364.00 |