SorLA Antibody (48): sc-136073

SorLA Antibody (48) is a mouse monoclonal IgG2a antibody that detects SorLA in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. SorLA, also known as Sorting protein-related receptor containing LDLR class A, is a Type I membrane protein that plays a crucial role in cellular processes, particularly in the uptake of lipoproteins and proteases. This multifunctional endocytic receptor is essential for maintaining lipid homeostasis and facilitating cell-cell interactions, which are vital for various physiological functions. SorLA is synthesized as a proreceptor and undergoes processing by furin-like propeptidases to achieve its mature form, allowing SorLA to effectively bind low-density lipoprotein (LDL) and transport LDL into cells via endocytosis. Additionally, SorLA interacts with receptor-associated protein (RAP) and the neuropeptide head activator (HA), highlighting SorLA′s importance in neuropeptide signaling and function. While predominantly expressed in the brain, particularly in the cerebral cortex, cerebellum, and occipital pole, SorLA is also found in other tissues such as the liver, spinal cord, kidney, testis, and pancreas, underscoring SorLA′s diverse biological roles. anti-SorLA antibody (48) is an invaluable tool for researchers investigating the intricate mechanisms of lipid metabolism and neuropeptide signaling in various biological contexts.

The preferred SorLA antibody is SorLA Antibody (7D7B11): sc-101426.