Sorbitol Dehydrogenase Antibody (E-8): sc-377200

Sorbitol Dehydrogenase Antibody (E-8) is a mouse monoclonal IgG3 kappa light chain antibody that detects Sorbitol Dehydrogenase (SORD) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SORD antibody (E-8) is available as the non-conjugated format. SORD, also known as L-iditol 2-dehydrogenase or SORD1, is a 357 amino acid enzyme that belongs to the zinc-containing alcohol dehydrogenase family and plays a crucial role in the metabolism of polyols. SORD is predominantly expressed in the kidney and lens of the eye, where SORD catalyzes the zinc-dependent conversion of sorbitol and xylitol to their corresponding ketoses, utilizing NAD+ as an oxidizing agent. This enzymatic activity is essential for the proper functioning of the sorbitol pathway, which is involved in sugar production and cellular energy metabolism. Disruptions in SORD function can lead to an accumulation of sorbitol, contributing to diabetic complications such as cataracts and microvascular issues. SORD monoclonal antibody (E-8) effectively detects SORD across multiple species, making SORD (E-8) antibody a valuable tool for researchers studying metabolic disorders and their implications in human health.

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Sorbitol Dehydrogenase Antibody (E-8) References:

1. X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase.  |  Pauly, TA., et al. 2003. Structure. 11: 1071-85. PMID: 12962626
2. Sorbitol dehydrogenase: structure, function and ligand design.  |  El-Kabbani, O., et al. 2004. Curr Med Chem. 11: 465-76. PMID: 14965227
3. Redox state-dependent and sorbitol accumulation-independent diabetic albuminuria in mice with transgene-derived human aldose reductase and sorbitol dehydrogenase deficiency.  |  Ii, S., et al. 2004. Diabetologia. 47: 541-548. PMID: 14968292
4. A potent sorbitol dehydrogenase inhibitor exacerbates sympathetic autonomic neuropathy in rats with streptozotocin-induced diabetes.  |  Schmidt, RE., et al. 2005. Exp Neurol. 192: 407-19. PMID: 15755558
5. Discovery of potential sorbitol dehydrogenase inhibitors from virtual screening.  |  Darmanin, C., et al. 2006. Med Chem. 2: 239-42. PMID: 16948469
6. A hydrogen-bonding network in mammalian sorbitol dehydrogenase stabilizes the tetrameric state and is essential for the catalytic power.  |  Hellgren, M., et al. 2007. Cell Mol Life Sci. 64: 3129-38. PMID: 17952367
7. Association between sorbitol dehydrogenase gene polymorphisms and type 2 diabetic retinopathy.  |  Szaflik, JP., et al. 2008. Exp Eye Res. 86: 647-52. PMID: 18289528
8. Structural organization of the human sorbitol dehydrogenase gene (SORD).  |  Iwata, T., et al. 1995. Genomics. 26: 55-62. PMID: 7782086
9. Structural and evolutionary characterization of the human sorbitol dehydrogenase gene duplication.  |  Carr, IM., et al. 1998. Mamm Genome. 9: 1042-8. PMID: 9880675

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Sorbitol Dehydrogenase Antibody (E-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Sorbitol Dehydrogenase Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Sorbitol Dehydrogenase Antibody (E-8) Specifications

Alternate Product Name: Sorbitol Dehydrogenase

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 307-343

Epitope Target: Sorbitol Dehydrogenase

Epitope Species: human

Product Reactivity/Detection: Sorbitol Dehydrogenase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Sorbitol Dehydrogenase Antibody (E-8): P: Blocking Peptide