Somatostatin Antibody (G-10): sc-55565

Somatostatin Antibody (G-10) is a mouse monoclonal IgG2b kappa light chain antibody that detects Somatostatin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Somatostatin (G-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Somatostatin is a crucial regulatory hormone that plays a significant role in inhibiting the release of several secondary hormones by binding to high-affinity G protein-coupled somatostatin receptors. This cyclic tetradecapeptide inhibits the secretion of key hormones such as growth hormone, insulin, and glucagon, maintaining hormonal balance. Somatostatin is predominantly located in the hypothalamus and pancreas, where this hormone regulates insulin synthesis, highlighting Somatostatin′s importance in glucose metabolism and overall endocrine function. Somatostatin exists in two active forms—Somatostatin-14 and Somatostatin-28—produced through alternate cleavage of a single preproprotein, with distinct expression patterns in the cerebellum at different developmental stages. Located on human chromosome 3q27, Somatostatin expression is critical for modulating neurotransmission rates in the central nervous system and influencing the proliferation of both normal and tumorigenic cells.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Somatostatin Antibody (G-10) References:

1. Effects of somatostatin, somatostatin analogs, and endothelial cell somatostatin gene transfer on smooth muscle cell proliferation in vitro.  |  Sarkar, R., et al. 1999. J Vasc Surg. 29: 685-93. PMID: 10194497
2. Somatostatin regulates hepatic growth hormone sensitivity by internalizing growth hormone receptors and by decreasing transcription of growth hormone receptor mRNAs.  |  Very, NM. and Sheridan, MA. 2007. Am J Physiol Regul Integr Comp Physiol. 292: R1956-62. PMID: 17272663
3. Synthesis of somatostatin analogues containing C-terminal adamantane and their antiproliferative properties.  |  Miyazaki, A., et al. 2008. J Med Chem. 51: 5121-4. PMID: 18680358
4. Somatostatin analogues inhibit cancer cell proliferation in an SSTR2-dependent manner via both cytostatic and cytotoxic pathways.  |  Zou, Y., et al. 2009. Oncol Rep. 21: 379-86. PMID: 19148511
5. Somatostatin antagonist analogue stimulates growth in rats.  |  Spencer, GS. and Hallett, KG. 1985. Life Sci. 37: 27-30. PMID: 2861550
6. Pancreatic somatostatin-like immunoreactivity suppresses gastric acid secretion in rats.  |  Zyznar, E., et al. 1979. Life Sci. 24: 1195-9. PMID: 449619
7. Somatostatin antagonist analog increases GH, insulin, and glucagon release in the rat.  |  Fries, JL., et al. 1982. Peptides. 3: 811-4. PMID: 6129618
8. Structure-activity relationships of somatostatin analogs in the rabbit ileum and the rat colon.  |  Rosenthal, LE., et al. 1983. J Clin Invest. 71: 840-9. PMID: 6131906
9. Somatostatin-like immunoreactivity is found in dendritic guard cells of human sweat ducts.  |  Johansson, O., et al. 1993. Peptides. 14: 401-3. PMID: 8097870
10. Somatostatin decreases somatostatin messenger ribonucleic acid levels in the rat periventricular nucleus.  |  Aguila, MC. 1998. Peptides. 19: 1573-9. PMID: 9864065

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Somatostatin Antibody (G-10) has 44 citations in a variety of scientific publications.

Primary antibodies like Anti-Somatostatin Antibody (G-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Somatostatin Antibody (G-10) Specifications

Alternate Product Name: Somatostatin

Product Clone Name: G-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-106

Epitope Target: Somatostatin

Epitope Species: human

Product Reactivity/Detection: Somatostatin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 44 citations in various scientific publications

Available Conjugates/Forms for Somatostatin Antibody (G-10): AC: Agarose, AF405: Alexa Fluor^® 405, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Somatostatin antibody is Somatostatin Antibody (H-11): sc-74556.