Somatostatin Antibody (D-12): sc-25262

Somatostatin Antibody (D-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects Somatostatin of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Somatostatin antibody (D-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Somatostatin is a crucial regulatory hormone that plays a significant role in inhibiting the release of several secondary hormones by binding to high-affinity G protein-coupled somatostatin receptors. This cyclic tetradecapeptide is essential for maintaining hormonal balance, as Somatostatin inhibits the secretion of key hormones such as growth hormone, insulin, and glucagon. Somatostatin is predominantly located in the hypothalamus and pancreas, where this hormone is involved in the regulation of insulin synthesis, thereby influencing glucose metabolism. The active forms of somatostatin, namely Somatostatin-14 and Somatostatin-28, are produced through the cleavage of a single preproprotein, with distinct expression patterns observed in the cerebellum at different developmental stages. Somatostatin′s impact extends to the central nervous system, where this hormone modulates neurotransmission and cell proliferation, making Somatostatin a vital component in both normal physiological processes and in the context of tumorigenesis. The gene encoding Somatostatin is located on human chromosome 3q27, underscoring Somatostatin′s importance in human health and disease.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Somatostatin Antibody (D-12) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Somatostatin Antibody (D-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Somatostatin Antibody (D-12) Specifications

Alternate Product Name: Somatostatin

Product Clone Name: D-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-106

Epitope Target: Somatostatin

Epitope Species: human

Product Reactivity/Detection: Somatostatin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Somatostatin Antibody (D-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Somatostatin antibody is Somatostatin Antibody (H-11): sc-74556.