Soggy-1 Antibody (H-11): sc-515409

Soggy-1 Antibody (H-11) is a mouse monoclonal IgG1 antibody that detects Soggy-1 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Soggy-1, a secreted antagonist of the Wnt signaling pathway, plays a crucial role in regulating developmental processes, particularly in preimplantation mouse embryos and developing neural tissue, as well as in adult testis tissue. Anti-Soggy-1 antibody (H-11) enables researchers to study how Soggy-1 modulates Wnt activity, ensuring proper spatial and temporal patterns during embryogenesis and organogenesis. Notably, Soggy-1 undergoes post-translational modification through glycosylation, which can influence stability, localization, and interaction with other proteins. These modifications are essential for Soggy-1′s function, as they can affect binding affinity to Wnt ligands and overall regulatory capacity within the Wnt signaling pathway. The molecular weight of Soggy-1 can vary depending on the tissue and cell type, reflecting the complexity of regulation and significance in developmental biology. Soggy-1 monoclonal antibody (H-11) serves as an invaluable tool for researchers studying the intricacies of Wnt signaling and its implications in developmental processes and diseases.

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Soggy-1 Antibody (H-11) References:

1. DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome during mammalian spermatogenesis.  |  Kohn, MJ., et al. 2005. Mol Reprod Dev. 71: 516-22. PMID: 15892050
2. Function and biological roles of the Dickkopf family of Wnt modulators.  |  Niehrs, C. 2006. Oncogene. 25: 7469-81. PMID: 17143291
3. Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice.  |  Ramanathan, P., et al. 2008. BMC Genomics. 9: 197. PMID: 18442417
4. Dickkopf-like1 regulates postpubertal spermatocyte apoptosis and testosterone production.  |  Dakhova, O., et al. 2009. Endocrinology. 150: 404-12. PMID: 18818293
5. Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse.  |  Abel, MH., et al. 2009. J Mol Endocrinol. 42: 291-303. PMID: 19136570
6. The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein.  |  Reynard, LN., et al. 2009. Biol Reprod. 81: 250-7. PMID: 19176879
7. The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility.  |  Kaneko, KJ., et al. 2010. Fertil Steril. 93: 1526-32. PMID: 19596310
8. The acrosomal protein Dickkopf-like 1 (DKKL1) facilitates sperm penetration of the zona pellucida.  |  Kohn, MJ., et al. 2010. Fertil Steril. 93: 1533-7. PMID: 19596312
9. Developmental expression and function of DKKL1/Dkkl1 in humans and mice.  |  Yan, Q., et al. 2012. Reprod Biol Endocrinol. 10: 51. PMID: 22817830
10. Region-specific expression of Dickkopf-like1 in the adult brain. Abbreviated title: Dkkl1 in the adult brain.  |  Sibbe, M. and Jarowyj, J. 2013. Neurosci Lett. 535: 84-9. PMID: 23295900

The preferred Soggy-1 antibody is Soggy-1 Antibody (E-12): sc-271563.