Superoxide Dismutase 2/SOD2 Antibody (B-1): sc-133254

SOD-2 Antibody (B-1) is a mouse monoclonal IgG2b kappa light chain antibody raised against amino acids 1-222, representing the full-length Superoxide Dismutase 2 (SOD2) protein of human origin, and is reactive with mouse, rat, and human species. SOD2, also known as manganese superoxide dismutase (MnSOD), is a vital mitochondrial enzyme that catalyzes the dismutation of superoxide anion into hydrogen peroxide and oxygen, serving as a primary defense against oxidative stress within cells. Synthesized in the cytosol as a precursor protein, SOD2 undergoes crucial post-translational modifications, including mitochondrial targeting and cleavage of its N-terminal signal sequence, enabling proper localization and activation within the mitochondrial matrix. These post-translational modifications are essential for SOD2 to function effectively in mitigating reactive oxygen species (ROS) generated during cellular respiration. Dysregulation or mutation in SOD2, including alterations in its post-translational modifications, is linked to numerous diseases, such as neurodegenerative conditions like Alzheimer′s and Parkinson′s, as well as ischemic heart disease and idiopathic dilated cardiomyopathy. Anti-SOD2 antibody (B-1) is validated for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA), making SOD2 (B-1) antibody an invaluable tool for researchers investigating the functional and pathological roles of SOD2. Anti-SOD2 antibody (B-1) is available in non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and Alexa Fluor® conjugates, offering flexibility for diverse experimental needs.

The preferred Superoxide Dismutase 2/SOD2 antibody is Superoxide Dismutase 2/SOD2 Antibody (A-2): sc-133134.