SNX4 Antibody (B-4): sc-271147
- SNX4 Antibody (B-4) is a mouse monoclonal IgG2a SNX4 antibody provided at 200 µg/ml
- raised against a peptide mapping within an internal region of SNX4 of human origin
- SNX4 Antibody (B-4) is recommended for detection of SNX4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- Anti-SNX4 Antibody (B-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for SNX4 Antibody (B-4) for WB applications. These reagents are now offered in bundles with SNX4 Antibody (B-4) (see ordering information below).
SNX4 Antibody (B-4) is a mouse monoclonal IgG2a antibody that detects SNX4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNX4 (B-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SNX4 plays a crucial role in intracellular trafficking and sorting of membrane proteins, which is vital for maintaining cellular homeostasis and regulating signaling pathways. Specifically, SNX4 is involved in the endosomal sorting of receptors, including the epidermal growth factor receptor, thereby influencing receptor degradation and recycling processes. This function is essential for modulating cellular responses to growth factors and ensuring proper signal transduction. Additionally, SNX4 shares structural similarities with other sorting nexins, such as SNX1 and SNX2, which contain a phox homology (PX) domain that facilitates their interaction with phosphoinositides and membrane compartments. SNX4′s ability to form complexes with other sorting nexins and various cellular proteins underscores its importance in the dynamic regulation of membrane trafficking and receptor signaling, making SNX4 a valuable target for research in cell biology and related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SNX4 Antibody (B-4) References:
- Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain. | Opresko, LK., et al. 1995. J Biol Chem. 270: 4325-33. PMID: 7876194
- Signal-dependent membrane protein trafficking in the endocytic pathway. | Trowbridge, IS., et al. 1993. Annu Rev Cell Biol. 9: 129-61. PMID: 8280459
- Enhanced degradation of EGF receptors by a sorting nexin, SNX1. | Kurten, RC., et al. 1996. Science. 272: 1008-10. PMID: 8638121
- Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains? | Ponting, CP. 1996. Protein Sci. 5: 2353-7. PMID: 8931154
- A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. | Horazdovsky, BF., et al. 1997. Mol Biol Cell. 8: 1529-41. PMID: 9285823
- Identification of a family of sorting nexin molecules and characterization of their association with receptors. | Haft, CR., et al. 1998. Mol Cell Biol. 18: 7278-87. PMID: 9819414
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNX4 Antibody (B-4) | sc-271147 | 200 µg/ml | $316.00 | |||
SNX4 Antibody (B-4): m-IgG Fc BP-HRP Bundle | sc-525788 | 200 µg Ab; 10 µg BP | $354.00 | |||
SNX4 Antibody (B-4): m-IgG2a BP-HRP Bundle | sc-546415 | 200 µg Ab; 10 µg BP | $354.00 | |||
SNX4 Antibody (B-4) AC | sc-271147 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SNX4 Antibody (B-4) HRP | sc-271147 HRP | 200 µg/ml | $316.00 | |||
SNX4 Antibody (B-4) FITC | sc-271147 FITC | 200 µg/ml | $330.00 | |||
SNX4 Antibody (B-4) PE | sc-271147 PE | 200 µg/ml | $343.00 | |||
SNX4 Antibody (B-4) Alexa Fluor® 488 | sc-271147 AF488 | 200 µg/ml | $357.00 | |||
SNX4 Antibody (B-4) Alexa Fluor® 546 | sc-271147 AF546 | 200 µg/ml | $357.00 | |||
SNX4 Antibody (B-4) Alexa Fluor® 594 | sc-271147 AF594 | 200 µg/ml | $357.00 | |||
SNX4 Antibody (B-4) Alexa Fluor® 647 | sc-271147 AF647 | 200 µg/ml | $357.00 | |||
SNX4 Antibody (B-4) Alexa Fluor® 680 | sc-271147 AF680 | 200 µg/ml | $357.00 | |||
SNX4 Antibody (B-4) Alexa Fluor® 790 | sc-271147 AF790 | 200 µg/ml | $357.00 | |||
SNX4 (B-4) Neutralizing Peptide | sc-271147 P | 100 µg/0.5 ml | $68.00 |