SNX17 Antibody (H-10): sc-166957

SNX17 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects SNX17 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNX17 (H-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SNX17 protein plays a crucial role in intracellular trafficking and is essential for maintaining proper levels of lipoprotein receptor-related protein (LRP) on the cell surface by facilitating recycling. SNX17 is characterized by the presence of a phox homology (PX) domain, which is vital for interaction with phosphatidylinositol-3-phosphate, allowing SNX17 to associate with membranes. SNX17 contains a FERM domain that enhances binding affinity to LRP, ensuring effective regulation of receptor levels. Research has shown that SNX17 is predominantly localized to the limiting membrane and recycling tubules of early endosomes, highlighting importance in the endocytic pathway and cellular sorting mechanisms. SNX17 gene is located on chromosome 2, and ubiquitous expression underscores fundamental role in cellular processes across various tissues.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SNX17 Antibody (H-10) References:

1. A new member of the sorting nexin family interacts with the C-terminus of P-selectin.  |  Florian, V., et al. 2001. Biochem Biophys Res Commun. 281: 1045-50. PMID: 11237770
2. The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.  |  Stockinger, W., et al. 2002. EMBO J. 21: 4259-67. PMID: 12169628
3. Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17.  |  Burden, JJ., et al. 2004. J Biol Chem. 279: 16237-45. PMID: 14739284
4. Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin.  |  Williams, R., et al. 2004. Mol Biol Cell. 15: 3095-105. PMID: 15121882
5. Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.  |  Knauth, P., et al. 2005. J Mol Biol. 347: 813-25. PMID: 15769472
6. Sorting nexin 17 facilitates LRP recycling in the early endosome.  |  van Kerkhof, P., et al. 2005. EMBO J. 24: 2851-61. PMID: 16052210
7. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.  |  Nomura, N., et al. 1994. DNA Res. 1: 223-9. PMID: 7584044

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNX17 Antibody (H-10) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-SNX17 Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNX17 Antibody (H-10) Specifications

Alternate Product Name: SNX17

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 270-470

Epitope Target: SNX17

Epitope Species: human

Product Reactivity/Detection: SNX17

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for SNX17 Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin