SNX17 Antibody (E-12): sc-166597
- SNX17 Antibody (E-12) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 416-429 near the C-terminus of SNX17 of human origin
- recommended for detection of SNX17 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SNX17 Antibody (E-12). This work is in progress.
SNX17 Antibody (E-12) is a mouse monoclonal IgM antibody that detects SNX17 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). SNX17 plays a crucial role in intracellular trafficking and cellular sorting, particularly in regulating cell surface levels of lipoprotein receptor-related protein (LRP) by facilitating recycling. SNX17 is characterized by a unique phox homology (PX) domain, which is essential for interaction with phosphatidylinositol-3-phosphate, allowing membrane association effectively. The presence of a FERM domain and carboxyl-terminal region enhances binding affinity to LRP, ensuring proper cellular function and signaling. Research has shown SNX17 is predominantly localized to limiting membrane and recycling tubules of early endosomes, highlighting importance in maintaining cellular homeostasis and dynamic regulation of receptor levels on cell surface. Anti-SNX17 antibody (E-12) serves as an invaluable tool for researchers studying mechanisms of intracellular trafficking and receptor recycling.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNX17 Antibody (E-12) | sc-166597 | 200 µg/ml | $316.00 | |||
SNX17 (E-12) Neutralizing Peptide | sc-166597 P | 100 µg/0.5 ml | $68.00 |