SNX1 Antibody (B-8): sc-376376

SNX1 Antibody (B-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Sorting nexin-1 (SNX1) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-SNX1 antibody (B-8) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. Sorting nexin-1 plays a crucial role in intracellular trafficking, particularly in transport and degradation of epidermal growth factor receptor (EGFR). SNX1 facilitates EGFR movement to lysosomes, which is essential for regulating receptor levels on cell surfaces and modulating cellular responses to growth factors. Proper functioning of SNX1 maintains cellular homeostasis and prevents aberrant signaling that can lead to diseases such as cancer. SNX1 interacts with other sorting nexins, including SNX2 and SNX4, which share structural similarities and contribute to a network of protein interactions important for various cellular processes. SNX1′s ability to form complexes with other proteins underscores SNX1′s significance in regulating receptor trafficking and signaling pathways.

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SNX1 Antibody (B-8) References:

1. Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor.  |  Chin, LS., et al. 2001. J Biol Chem. 276: 7069-78. PMID: 11110793
2. Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1.  |  Wang, Y., et al. 2002. Mol Biol Cell. 13: 1965-76. PMID: 12058063
3. Sorting nexin 1 down-regulation promotes colon tumorigenesis.  |  Nguyen, LN., et al. 2006. Clin Cancer Res. 12: 6952-9. PMID: 17145813
4. Expression and purification of the SNX1/SNX6 complex.  |  Yong, X., et al. 2018. Protein Expr Purif. 151: 93-98. PMID: 29908913
5. Increased AT1 receptor expression mediates vasoconstriction leading to hypertension in Snx1-/- mice.  |  Liu, C., et al. 2021. Hypertens Res. 44: 906-917. PMID: 33972750
6. Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson's disease.  |  Yoshida, S., et al. 2024. Cell Death Discov. 10: 290. PMID: 38886344
7. Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain.  |  Opresko, LK., et al. 1995. J Biol Chem. 270: 4325-33. PMID: 7876194
8. Signal-dependent membrane protein trafficking in the endocytic pathway.  |  Trowbridge, IS., et al. 1993. Annu Rev Cell Biol. 9: 129-61. PMID: 8280459
9. Enhanced degradation of EGF receptors by a sorting nexin, SNX1.  |  Kurten, RC., et al. 1996. Science. 272: 1008-10. PMID: 8638121
10. Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?  |  Ponting, CP. 1996. Protein Sci. 5: 2353-7. PMID: 8931154
11. A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor.  |  Horazdovsky, BF., et al. 1997. Mol Biol Cell. 8: 1529-41. PMID: 9285823
12. Identification of a family of sorting nexin molecules and characterization of their association with receptors.  |  Haft, CR., et al. 1998. Mol Cell Biol. 18: 7278-87. PMID: 9819414

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNX1 Antibody (B-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SNX1 Antibody (B-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNX1 Antibody (B-8) Specifications

Alternate Product Name: SNX1

Product Clone Name: B-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 21-135

Epitope Target: SNX1

Epitope Species: human

Product Reactivity/Detection: SNX1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SNX1 Antibody (B-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin