SNX1 Antibody (51): sc-136247
- SNX1 Antibody (51) is a mouse monoclonal IgG1, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against amino acids 1-108 of SNX1 of human origin
- recommended for detection of SNX1 of human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SNX1 Antibody (51). This work is in progress.
SNX1 Antibody (51) is a mouse monoclonal IgG1 antibody that detects sorting nexin 1 (SNX1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SNX1 plays a crucial role in intracellular trafficking, particularly in the transport and degradation of the epidermal growth factor (EGF) receptor, which is vital for regulating cellular responses to growth signals. By facilitating the movement of the EGF receptor to lysosomes, SNX1 helps maintain cellular homeostasis and prevent excessive signaling that could lead to uncontrolled cell proliferation. SNX1 is characterized by its phox homology (PX) domain, which is essential for interaction with various receptor types, including receptor tyrosine kinases like EGF, platelet-derived growth factor (PDGF), and insulin receptors. SNX1 is part of a larger family of sorting nexins that exhibit diverse tissue distribution patterns and can form multisubunit complexes with other cellular proteins, enhancing functional versatility. SNX3, while sharing the PX domain, has distinct binding affinities, highlighting the specificity and importance of SNX1 in cellular signaling pathways. With an ability to interact with multiple proteins and significant role in receptor trafficking, SNX1 is a key player in maintaining the balance of signaling pathways within the cell.
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SNX1 Antibody (51) References:
- Structural and functional characterization of the human gene for sorting nexin 1 (SNX1). | Shank, BB., et al. 2001. DNA Cell Biol. 20: 287-96. PMID: 11410165
- Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor. | Pons, V., et al. 2003. J Biol Chem. 278: 21155-61. PMID: 12657642
- Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. | Carlton, J., et al. 2004. Curr Biol. 14: 1791-800. PMID: 15498486
- Regulation of P2Y1 receptor traffic by sorting Nexin 1 is retromer independent. | Nisar, S., et al. 2010. Traffic. 11: 508-19. PMID: 20070609
- Sorting nexin-1 is a candidate tumor suppressor and potential prognostic marker in gastric cancer. | Zhan, XY., et al. 2018. PeerJ. 6: e4829. PMID: 29868263
- A Critical Role for Sorting Nexin 1 in the Trafficking of Metabotropic Glutamate Receptors. | Sharma, R., et al. 2018. J Neurosci. 38: 8605-8620. PMID: 30143569
- Sorting nexin 1 loss results in increased oxidative stress and hypertension. | Yang, J., et al. 2020. FASEB J. 34: 7941-7957. PMID: 32293069
- The plant-unique protein DRIF1 coordinates with sorting nexin 1 to regulate membrane protein homeostasis. | Zhu, Y., et al. 2023. Plant Cell. 35: 4217-4237. PMID: 37647529
- Canonical and Non-Canonical Roles of SNX1 and SNX2 in Endosomal Membrane Dynamics. | Da Graça, J. and Morel, E. 2023. Contact (Thousand Oaks). 6: 25152564231217867. PMID: 38033809
- A peptide derived from sorting nexin 1 inhibits HPV16 entry, retrograde trafficking, and L2 membrane spanning. | Li, S., et al. 2024. Tumour Virus Res. 18: 200287. PMID: 38909779
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNX1 Antibody (51) | sc-136247 | 50 µg/0.5 ml | $322.00 |