Snurportin-1 Antibody (B-12): sc-137133

Snurportin-1 Antibody (B-12) is a mouse monoclonal IgG1 antibody that detects Snurportin-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Snurportin-1, also known as SNUPN, KPNBL, or RNUT1 (RNA U transporter 1), is a crucial nuclear import adaptor protein that plays a significant role in the transport of U small nuclear ribonucleoproteins (U snRNPs) into the nucleus, a vital step in the maturation of the spliceosome. This protein is characterized by its unique structure, which includes an N-terminal importin β-binding (IBB) domain and a trimethylguanosine (m3G)-cap binding domain, allowing Snurportin-1 to specifically recognize and bind the terminal 2,2,7-m3G-cap at the 5′ end of U snRNPs. The interaction between Snurportin-1, U snRNPs, and Importin β forms a complex that is essential for the nuclear import process. Once inside the nucleus, Snurportin-1 may localize to Cajal bodies, depending on the specific U snRNP involved, such as U1 or U2. Additionally, Snurportin-1 is recycled back to the cytoplasm by CRM1, ensuring continuous facilitation of multiple rounds of U snRNP import, thereby maintaining the efficiency of spliceosome assembly and function. Snurportin-1 (B-12) antibody is an invaluable tool for researchers studying RNA processing and spliceosome dynamics in various biological contexts.

The preferred Snurportin-1 antibody is Snurportin-1 Antibody (F-2): sc-166006.