SNRPC Antibody (4H12): sc-101549
- SNRPC Antibody (4H12) is a rat monoclonal IgG2a SNRPC antibody, cited in 6 publications, provided at 200 µg/ml
- raised against full-length recombinant SNRPC of mouse origin
- SNRPC Antibody (4H12) is recommended for detection of SNRPC of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SNRPC Antibody (4H12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SNRPC Antibody (4H12). This work is in progress.
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SNRPC Antibody (4H12) is a rat monoclonal IgG2a antibody that detects SNRPC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SNRPC antibody (4H12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SNRPC protein, or small nuclear ribonucleoprotein polypeptide C, is a 159 amino acid protein primarily localized in the nucleus, where SNRPC plays a crucial role in the assembly and function of the spliceosome, a complex responsible for processing pre-mRNA into mature mRNA. This function is vital for gene expression regulation and the production of functional proteins, making SNRPC essential for cellular homeostasis and proper development. The gene encoding SNRPC is located on human chromosome 6, a region associated with various genetic disorders, including early onset intestinal cancer and neurodegenerative diseases. SNRPC′s ability to interact with other proteins, such as U1 SnRNP 70, further underscores SNRPC′s importance in ribonucleoprotein-related events, highlighting SNRPC′s potential as a target for research into splicing mechanisms and related pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SNRPC Antibody (4H12) References:
- The splicing factor U1C represses EWS/FLI-mediated transactivation. | Knoop, LL. and Baker, SJ. 2000. J Biol Chem. 275: 24865-71. PMID: 10827180
- The U1 snRNP protein U1C recognizes the 5' splice site in the absence of base pairing. | Du, H. and Rosbash, M. 2002. Nature. 419: 86-90. PMID: 12214237
- The structure and biochemical properties of the human spliceosomal protein U1C. | Muto, Y., et al. 2004. J Mol Biol. 341: 185-98. PMID: 15312772
- Protein stoichiometry of a multiprotein complex, the human spliceosomal U1 small nuclear ribonucleoprotein: absolute quantification using isotope-coded tags and mass spectrometry. | Hochleitner, EO., et al. 2005. J Biol Chem. 280: 2536-42. PMID: 15525645
- Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide. | Yamamoto, K., et al. 1988. J Immunol. 140: 311-7. PMID: 2961811
- Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals. | Sillekens, PT., et al. 1988. Nucleic Acids Res. 16: 8307-21. PMID: 2971157
- Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C. | Nelissen, RL., et al. 1997. Gene. 184: 273-8. PMID: 9031639
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNRPC Antibody (4H12) | sc-101549 | 200 µg/ml | $322.00 | |||
SNRPC Antibody (4H12) AC | sc-101549 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SNRPC Antibody (4H12) HRP | sc-101549 HRP | 200 µg/ml | $322.00 | |||
SNRPC Antibody (4H12) FITC | sc-101549 FITC | 200 µg/ml | $336.00 | |||
SNRPC Antibody (4H12) PE | sc-101549 PE | 200 µg/ml | $349.00 | |||
SNRPC Antibody (4H12) Alexa Fluor® 488 | sc-101549 AF488 | 200 µg/ml | $364.00 | |||
SNRPC Antibody (4H12) Alexa Fluor® 546 | sc-101549 AF546 | 200 µg/ml | $364.00 | |||
SNRPC Antibody (4H12) Alexa Fluor® 594 | sc-101549 AF594 | 200 µg/ml | $364.00 | |||
SNRPC Antibody (4H12) Alexa Fluor® 647 | sc-101549 AF647 | 200 µg/ml | $364.00 | |||
SNRPC Antibody (4H12) Alexa Fluor® 680 | sc-101549 AF680 | 200 µg/ml | $364.00 | |||
SNRPC Antibody (4H12) Alexa Fluor® 790 | sc-101549 AF790 | 200 µg/ml | $364.00 |