SNRK Antibody (A-3): sc-398557

SNRK Antibody (A-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects SNRK protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNRK (A-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SNRK, also known as HSNFRK, is a 765 amino acid nuclear protein that belongs to the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases, which are crucial for various cellular processes. SNRK plays a key role in protein phosphorylation and dephosphorylation, a vital mechanism for intracellular signal transduction in eukaryotic organisms. This process regulates hematopoietic cell proliferation and differentiation, particularly in hematopoietic progenitor cells and leukemic cell lines where SNRK shows expression. SNRK activation by LKB1 may regulate low potassium-induced apoptosis in cerebellar granule neurons, highlighting SNRK′s importance in neuronal health and function. Located on human chromosome 3 among over 1,100 genes, including those associated with cancer, SNRK represents a promising target for therapeutic interventions in hematological malignancies and neurodegenerative diseases.

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SNRK Antibody (A-3) References:

1. SNRK, a member of the SNF1 family, is related to low K(+)-induced apoptosis of cultured rat cerebellar granule neurons.  |  Yoshida, K., et al. 2000. Brain Res. 873: 274-82. PMID: 10930554
2. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases.  |  Kertesz, N., et al. 2002. Gene. 294: 13-24. PMID: 12234663
3. Expression cloning of a variety of novel protein kinases in Lotus japonicus.  |  Kameshita, I., et al. 2005. J Biochem. 137: 33-9. PMID: 15713881
4. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.  |  Jaleel, M., et al. 2005. FEBS Lett. 579: 1417-23. PMID: 15733851
5. Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates.  |  Chun, CZ., et al. 2009. Blood. 113: 1192-9. PMID: 18723694
6. Dusp-5 and Snrk-1 coordinately function during vascular development and disease.  |  Pramanik, K., et al. 2009. Blood. 113: 1184-91. PMID: 18927432
7. The regulation and function of mammalian AMPK-related kinases.  |  Bright, NJ., et al. 2009. Acta Physiol (Oxf). 196: 15-26. PMID: 19245655
8. Snf1-related protein kinases (SnRKs) act within an intricate network that links metabolic and stress signalling in plants.  |  Halford, NG. and Hey, SJ. 2009. Biochem J. 419: 247-59. PMID: 19309312
9. Negative feedback of SNRK to circ-SNRK regulates cardiac function post-myocardial infarction.  |  Wang, ZY., et al. 2022. Cell Death Differ. 29: 709-721. PMID: 34621049
10. DNA Damage and Nuclear Morphological Changes in Cardiac Hypertrophy Are Mediated by SNRK Through Actin Depolymerization.  |  Stanczyk, PJ., et al. 2023. Circulation. 148: 1582-1592. PMID: 37721051
11. SNRK modulates mTOR-autophagy pathway for liver lipid homeostasis in MAFLD.  |  Lin, S., et al. 2025. Mol Ther. 33: 279-296. PMID: 39521960
12. Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases.  |  Becker, W., et al. 1996. Eur J Biochem. 235: 736-43. PMID: 8654423

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNRK Antibody (A-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SNRK Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNRK Antibody (A-3) Specifications

Alternate Product Name: SNRK

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 335-448

Epitope Target: SNRK

Epitope Species: human

Product Reactivity/Detection: SNRK

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SNRK Antibody (A-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin