SNAP 25 Antibody (20): sc-136267
- SNAP 25 Antibody (20) is a mouse monoclonal IgG1, cited in 4 publications, provided at 50 µg/0.5 ml
- raised against amino acids 8-29 of SNAP 25 of mouse origin
- recommended for detection of SNAP 25 of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SNAP 25 Antibody (20). This work is in progress.
SNAP 25 Antibody (20) is a mouse monoclonal IgG1 antibody that detects SNAP 25 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SNAP 25 is a crucial component of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, which plays a vital role in neurotransmitter release at synapses. SNAP 25 is primarily located in the presynaptic membrane of neurons, where SNAP 25 facilitates the fusion of synaptic vesicles with the plasma membrane, allowing for efficient release of neurotransmitters into the synaptic cleft. Proper functioning of SNAP 25 is essential for synaptic transmission and communication between neurons, making SNAP 25 a key player in various neurological processes. Dysregulation of SNAP 25 has been implicated in several neurological disorders, including schizophrenia and autism spectrum disorders, highlighting SNAP 25′s importance in maintaining synaptic health and function. Anti-SNAP 25 antibody (20) provides a reliable tool for researchers studying synaptic mechanisms and the molecular underpinnings of neurodegenerative diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SNAP 25 Antibody (20) References:
- Molecular analysis of SNAP-25 function in exocytosis. | Graham, ME., et al. 2002. Ann N Y Acad Sci. 971: 210-21. PMID: 12438121
- SNAP-25 is also an iron-sulfur protein. | Huang, Q., et al. 2008. FEBS Lett. 582: 1431-6. PMID: 18375205
- Differential expression of SNAP-25 family proteins in the mouse brain. | Yamamori, S., et al. 2011. J Comp Neurol. 519: 916-32. PMID: 21280044
- Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses. | Antonucci, F., et al. 2013. EMBO Rep. 14: 645-51. PMID: 23732542
- SNAP-25 regulates spine formation through postsynaptic binding to p140Cap. | Tomasoni, R., et al. 2013. Nat Commun. 4: 2136. PMID: 23868368
- Serum miRNAs Expression and SNAP-25 Genotype in Alzheimer's Disease. | Agostini, S., et al. 2019. Front Aging Neurosci. 11: 52. PMID: 30914946
- Investigation of possible associations of the BDNF, SNAP-25 and SYN III genes with the neurocognitive measures: BDNF and SNAP-25 genes might be involved in attention domain, SYN III gene in executive function. | Bolat, H., et al. 2022. Nord J Psychiatry. 76: 610-615. PMID: 35077325
- Rabphilin 3A binds the N-peptide of SNAP-25 to promote SNARE complex assembly in exocytosis. | Li, T., et al. 2022. Elife. 11: PMID: 36173100
- Role of SNAP25 on the occurrence and development of eosinophilic gastritis. | Zhang, J., et al. 2023. Medicine (Baltimore). 102: e34377. PMID: 37478220
- Dynamics of synaptic damage in severe traumatic brain injury revealed by cerebrospinal fluid SNAP-25 and VILIP-1. | Olde Heuvel, F., et al. 2024. J Neurol Neurosurg Psychiatry. 95: 1158-1167. PMID: 38825349
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SNAP 25 Antibody (20) | sc-136267 | 50 µg/0.5 ml | $316.00 |