SMTNL1 Antibody (G-7): sc-390369

SMTNL1 Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects SMTNL1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMTNL1 (G-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SMTNL1, also known as smoothelin-like 1, is a crucial cytoskeletal protein that plays a significant role in smooth muscle cell contractile function, where SMTNL1 is exclusively expressed. SMTNL1 contains a calponin-homology domain and is involved in actin cytoskeleton organization, which is essential for maintaining smooth muscle tissue structural integrity and contractility. SMTNL1 interacts with actin stress fibers, contributing to smooth muscle contraction regulation, but does not associate with desmin, highlighting SMTNL1′s specific role in smooth muscle physiology. SMTNL1 gene is located on human chromosome 11, a region associated with several genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome, underscoring SMTNL1′s importance in both normal physiology and disease states.

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SMTNL1 Antibody (G-7) References:

1. A novel smoothelin-like, actin-binding protein required for choroidal fissure closure in zebrafish.  |  Kurita, R., et al. 2004. Biochem Biophys Res Commun. 313: 1092-100. PMID: 14706655
2. The 11q terminal deletion disorder: a prospective study of 110 cases.  |  Grossfeld, PD., et al. 2004. Am J Med Genet A. 129A: 51-61. PMID: 15266616
3. Human chromosome 11 DNA sequence and analysis including novel gene identification.  |  Taylor, TD., et al. 2006. Nature. 440: 497-500. PMID: 16554811
4. Wilms tumour: prognostic factors, staging, therapy and late effects.  |  Kaste, SC., et al. 2008. Pediatr Radiol. 38: 2-17. PMID: 18026723
5. Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.  |  Wooldridge, AA., et al. 2008. J Biol Chem. 283: 11850-9. PMID: 18310078
6. Solution structure of the calponin homology (CH) domain from the smoothelin-like 1 protein: a unique apocalmodulin-binding mode and the possible role of the C-terminal type-2 CH-domain in smooth muscle relaxation.  |  Ishida, H., et al. 2008. J Biol Chem. 283: 20569-78. PMID: 18477568
7. The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction.  |  Borman, MA., et al. 2009. Mol Cell Biochem. 327: 93-100. PMID: 19219534

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SMTNL1 Antibody (G-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-SMTNL1 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SMTNL1 Antibody (G-7) Specifications

Alternate Product Name: SMTNL1

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 255-287

Epitope Target: SMTNL1

Epitope Species: human

Product Reactivity/Detection: SMTNL1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for SMTNL1 Antibody (G-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin