Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The SMS (sphingomyelin synthase) family is a group of integral membrane proteins that includes SMS1 (sphingomyelin synthase 1) and SMS2 (sphingomyelin synthase 2). SMS1 is located in the Golgi apparatus, whereas SMS2 resides primarily at the plasma membrane. Both are bidirectional lipid cholinephosphotransferases which convert phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa, the direction of which depends on the relative concentrations of ceramide and diacylglycerol as phosphocholine acceptors. Therefore, sphingomyelin synthases are thought to be involved in both cell death and survival. Tricyclodecan-9-yl-xanthogenate (D609), a selective tumor cytotoxic agent, inhibits SMS activity, contributing to tumor cell cytotoxicity. SMS proteins are expressed in liver, muscle, heart, brain, stomach and kidney. SMS1 is expressed as four alternatively spliced mRNAs (SMS1α1, SMS1α2, SMS1β and SMS1γ) that translate into three different proteins (SMS1α, SMS1β and SMS1γ), which differ in their tissue distribution and function.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.