SMS1 Antibody (F-10): sc-166380

SMS1 Antibody (F-10) is a mouse monoclonal IgG2a antibody that detects sphingomyelin synthase 1 (SMS1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMS1 plays a crucial role in lipid metabolism, specifically in sphingomyelin synthesis, a vital component of cell membranes that influences membrane structure and function. SMS1 is primarily located in the Golgi apparatus, where SMS1 catalyzes the conversion of phosphatidylcholine and ceramide into sphingomyelin and diacylglycerol, and vice versa, depending on lipid concentrations. This localization allows SMS1 to regulate sphingolipid balance in cells, which is essential for maintaining cellular integrity and signaling pathways. Dysregulation of sphingomyelin synthesis has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting SMS1′s importance in both cell survival and apoptosis. Anti-SMS1 antibody (F-10) is particularly valuable for researchers studying lipid metabolism and its implications in health and disease, providing a reliable tool for detecting and analyzing SMS1 expression in various biological contexts.

The preferred SMS1 antibody is SMS1 Antibody (G-8): sc-133135.