SMCR7L Antibody (A-6): sc-514135
- SMCR7L Antibody (A-6) is a mouse monoclonal IgG2a κ SMCR7L antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 49-205 mapping near the N-terminus of SMCR7L of human origin
- SMCR7L Antibody (A-6) is recommended for detection of SMCR7L of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-SMCR7L Antibody (A-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SMCR7L Antibody (A-6) for WB applications. These reagents are now offered in bundles with SMCR7L Antibody (A-6) (see ordering information below).
QUICK LINKS
SMCR7L Antibody (A-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects SMCR7L of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SMCR7L (A-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SMCR7L, also known as Smith-Magenis syndrome chromosome region, candidate 7-like, is a 463 amino acid single-pass membrane protein encoded by a gene located on human chromosome 22, which is significant due to its association with various genetic disorders, including Smith-Magenis syndrome. SMCR7L localization within the cell membrane is crucial as SMCR7L plays a role in cellular signaling and communication, impacting processes such as cell growth and differentiation. Given that chromosome 22 harbors over 500 genes, mutations in this region can lead to a range of developmental and psychiatric disorders, highlighting the importance of studying SMCR7L in understanding these conditions. Additionally, SMCR7L potential interactions with other proteins may provide insights into functional pathways and therapeutic targets, making anti-SMCR7L antibody (A-6) an essential tool for researchers investigating molecular mechanisms underlying these diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SMCR7L Antibody (A-6) References:
- Chromosome 22 workshop report. | Schwab, SG. and Wildenauer, DB. 1999. Am J Med Genet. 88: 276-8. PMID: 10374745
- Disease genes and chromosomes: disease maps of the human genome. Chromosome 22. | Gilbert, F. 1998. Genet Test. 2: 89-97. PMID: 10464604
- Constitutional rearrangements of chromosome 22 as a cause of neurofibromatosis 2. | Tsilchorozidou, T., et al. 2004. J Med Genet. 41: 529-34. PMID: 15235024
- Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. | Paylor, R., et al. 2006. Proc Natl Acad Sci U S A. 103: 7729-34. PMID: 16684884
- Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia. | Arinami, T. 2006. J Hum Genet. 51: 1037-1045. PMID: 16969581
- Mutational spectrum of the NF2 gene: a meta-analysis of 12 years of research and diagnostic laboratory findings. | Ahronowitz, I., et al. 2007. Hum Mutat. 28: 1-12. PMID: 16983642
- BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility. | Zheng, X., et al. 2006. BMC Cancer. 6: 262. PMID: 17090304
- Deletion 22q11: spectrum of associated disorders. | Hay, BN. 2007. Semin Pediatr Neurol. 14: 136-9. PMID: 17980310
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SMCR7L Antibody (A-6) | sc-514135 | 200 µg/ml | $322.00 | |||
SMCR7L Antibody (A-6): m-IgG Fc BP-HRP Bundle | sc-531039 | 200 µg Ab; 10 µg BP | $361.00 | |||
SMCR7L Antibody (A-6): m-IgGκ BP-HRP Bundle | sc-524617 | 200 µg Ab, 40 µg BP | $361.00 | |||
SMCR7L Antibody (A-6): m-IgG2a BP-HRP Bundle | sc-547668 | 200 µg Ab; 10 µg BP | $361.00 | |||
SMCR7L Antibody (A-6) AC | sc-514135 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SMCR7L Antibody (A-6) HRP | sc-514135 HRP | 200 µg/ml | $322.00 | |||
SMCR7L Antibody (A-6) FITC | sc-514135 FITC | 200 µg/ml | $336.00 | |||
SMCR7L Antibody (A-6) PE | sc-514135 PE | 200 µg/ml | $349.00 | |||
SMCR7L Antibody (A-6) Alexa Fluor® 488 | sc-514135 AF488 | 200 µg/ml | $364.00 | |||
SMCR7L Antibody (A-6) Alexa Fluor® 546 | sc-514135 AF546 | 200 µg/ml | $364.00 | |||
SMCR7L Antibody (A-6) Alexa Fluor® 594 | sc-514135 AF594 | 200 µg/ml | $364.00 | |||
SMCR7L Antibody (A-6) Alexa Fluor® 647 | sc-514135 AF647 | 200 µg/ml | $364.00 | |||
SMCR7L Antibody (A-6) Alexa Fluor® 680 | sc-514135 AF680 | 200 µg/ml | $364.00 | |||
SMCR7L Antibody (A-6) Alexa Fluor® 790 | sc-514135 AF790 | 200 µg/ml | $364.00 |