SMC1α Antibody (H-6): sc-393171

SMC1α Antibody (H-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects SMC1α protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SMC1α antibody (H-6) is available as the non-conjugated form. SMC1α protein, also known as structural maintenance of chromosomes protein 1A, plays a crucial role in maintaining chromosome integrity during cell division. SMC1α protein is a 1,233 amino acid nuclear protein essential for sister chromatid cohesion, a process ensuring accurate chromosome segregation during mitosis. SMC1α protein is part of the cohesion complex, which is vital for holding sister chromatids together after DNA replication, thereby preventing aneuploidy and ensuring genomic stability. Additionally, SMC1α protein interacts with key proteins such as BRCA1, and SMC1α phosphorylation by ATM suggests significant involvement in DNA damage repair mechanisms. Mutations in the gene encoding SMC1α have been linked to Cornelia de Lange syndrome, a developmental disorder characterized by various physical and cognitive challenges. Anti-SMC1α antibody (H-6) effectively detects this important protein, making SMC1α monoclonal antibody (H-6) a valuable tool for researchers studying cell cycle regulation and related genetic disorders.

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SMC1α Antibody (H-6) References:

1. Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family.  |  Nishiwaki, T., et al. 1999. J Hum Genet. 44: 197-202. PMID: 10319587
2. Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions.  |  Strunnikov, AV. and Jessberger, R. 1999. Eur J Biochem. 263: 6-13. PMID: 10429180
3. Differential association of SMC1alpha and SMC3 proteins with meiotic chromosomes in wild-type and SPO11-deficient male mice.  |  James, RD., et al. 2002. Chromosome Res. 10: 549-60. PMID: 12498344
4. Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis.  |  Lee, J., et al. 2003. J Cell Sci. 116: 2781-90. PMID: 12759374
5. Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of cornelia de Lange syndrome with predominant mental retardation.  |  Deardorff, MA., et al. 2007. Am J Hum Genet. 80: 485-94. PMID: 17273969
6. Chromosome elimination in the interspecific hybrid medaka between Oryzias latipes and O. hubbsi.  |  Sakai, C., et al. 2007. Chromosome Res. 15: 697-709. PMID: 17603754
7. Cornelia de Lange syndrome mutations in SMC1A or SMC3 affect binding to DNA.  |  Revenkova, E., et al. 2009. Hum Mol Genet. 18: 418-27. PMID: 18996922
8. Cornelia de Lange syndrome, cohesin, and beyond.  |  Liu, J. and Krantz, ID. 2009. Clin Genet. 76: 303-14. PMID: 19793304
9. Spectrum and consequences of SMC1A mutations: the unexpected involvement of a core component of cohesin in human disease.  |  Mannini, L., et al. 2010. Hum Mutat. 31: 5-10. PMID: 19842212
10. Clinical problems and everyday abilities of a group of Italian adolescent and young adults with Cornelia de Lange syndrome.  |  Olioso, G., et al. 2009. Am J Med Genet A. 149A: 2532-7. PMID: 19876900
11. SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.  |  Strunnikov, AV., et al. 1993. J Cell Biol. 123: 1635-48. PMID: 8276886
12. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.  |  Schmiesing, JA., et al. 1998. Proc Natl Acad Sci U S A. 95: 12906-11. PMID: 9789013

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SMC1α Antibody (H-6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-SMC1α Antibody (H-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SMC1α Antibody (H-6) Specifications

Alternate Product Name: SMC1α

Product Clone Name: H-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1202-1233

Epitope Target: SMC1a

Epitope Species: human

Product Reactivity/Detection: SMC1α

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: avian

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for SMC1α Antibody (H-6): P: Blocking Peptide, X: TransCruz Reagent

The preferred SMC1 antibody is SMC1 Antibody (C2M): sc-56776.