SMC1α Activators
The chemical class of SMC1α Activators includes compounds that can indirectly influence the activity and function of SMC1α through various cellular mechanisms, primarily related to DNA damage response, repair pathways, and chromatin organization. These compounds, while not directly interacting with SMC1α, play crucial roles in modulating the cellular environment and signaling pathways that can lead to the activation or upregulation of SMC1α's function.
For instance, inhibitors of key kinases like ATR and ATM, as well as PARP inhibitors such as Olaparib, can enhance DNA repair mechanisms where SMC1α plays a significant role. The indirect activation can occur as a cellular response to the increased DNA damage or stress caused by these compounds. Additionally, agents that affect chromatin structure and gene expression, like HDAC inhibitors, also have the potential to modulate SMC1α's role in chromatin organization and maintenance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
A PARP inhibitor, Olaparib, leads to an accumulation of DNA breaks. This could indirectly enhance the activity of SMC1α as part of the DNA repair machinery. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 disrupts the interaction between p53 and MDM2. As p53 is involved in DNA damage response, this could indirectly lead to the activation of SMC1α. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits ATM and ATR kinases, potentially influencing DNA repair pathways and indirectly modulating SMC1α's role in these pathways. | ||||||
IC-87114 | 371242-69-2 | sc-364509 sc-364509A | 5 mg 50 mg | $140.00 $1060.00 | 1 | |
PI3K inhibitors can modulate signaling pathways involved in cell survival and stress response, potentially affecting SMC1α function. | ||||||
PI3K/HDAC Inhibitor | 1339928-25-4 | sc-364584 sc-364584A | 5 mg 10 mg | $347.00 $471.00 | ||
Histone deacetylase inhibitors affect chromatin structure and gene expression, which could indirectly influence SMC1α's role in chromatin organization. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibiting mTOR can affect cellular growth and stress responses, potentially modulating SMC1α activity in processes like DNA repair. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
A DNA crosslinking agent, Mitomycin C, induces DNA damage, potentially upregulating SMC1α activity in the DNA repair process. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
As a topoisomerase inhibitor, Camptothecin induces DNA damage, which could enhance the activity of SMC1α in DNA repair. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil causes DNA damage and stress, potentially leading to the activation of pathways involving SMC1α. | ||||||