SLPI Antibody (A-11): sc-374575

SLPI Antibody (A-11) is a mouse monoclonal IgM antibody that detects SLPI protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-SLPI antibody (A-11) is available as the non-conjugated form. Secretory leukocyte protease inhibitor (SLPI) is a crucial enzyme belonging to the α-1 antitrypsin antiprotein family, primarily produced by epithelial cells. SLPI is found in various bodily secretions, including parotid secretions, bronchial, nasal, and cervical mucus, as well as seminal fluid. One of the key functions of SLPI is regulating neutrophil-mediated inflammation, achieved through proteolysis and inhibition of leukocyte serine proteases, which include neutrophil and pancreatic proteases. SLPI interacts with specific proteins such as interferon regulatory factor 1 (IRF-1), which binds to the promoter region of SLPI and regulates expression. Inhibition of SLPI expression by IRF-1 co-expression highlights significance in inflammatory responses and suggests SLPI may play a role in modulating macrophage responses to lipopolysaccharides by inhibiting nitric oxide production. This multifaceted role of SLPI underscores importance in maintaining homeostasis during inflammatory processes and potential as a therapeutic target in diseases characterized by dysregulated inflammation.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SLPI Antibody (A-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-SLPI Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SLPI Antibody (A-11) Specifications

Alternate Product Name: SLPI

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 65-99

Epitope Target: SLPI

Epitope Species: mouse

Product Reactivity/Detection: SLPI

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for SLPI Antibody (A-11): P: Blocking Peptide

The preferred SLPI antibody is SLPI Antibody (F-12): sc-373802.