Slfn5 Antibody (4G2): sc-293255

Slfn5 Antibody (4G2) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Slfn5 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Slfn5 antibody (4G2) is available as the non-conjugated format. Slfn5, also known as schlafen family member 5, is an 891 amino acid protein that exists in multiple alternatively spliced isoforms and plays a crucial role in hematopoietic cell differentiation, which is essential for blood cell and immune system development. Slfn5 is encoded on human chromosome 17, a region comprising over 2.5% of the human genome and encoding more than 1,200 genes, including key tumor suppressor genes p53 and BRCA1. p53 maintains cellular genetic integrity by regulating cell fate decisions between DNA repair and apoptosis, while BRCA1 functions in DNA repair and has implications in hereditary breast and ovarian cancers. Understanding Slfn5 and its interactions within this genomic context can provide insights into potential roles in cancer biology and therapeutic strategies.

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Slfn5 Antibody (4G2) References:

1. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.  |  Geserick, P., et al. 2004. Int Immunol. 16: 1535-48. PMID: 15351786
2. BLIMP1 regulates cell growth through repression of p53 transcription.  |  Yan, J., et al. 2007. Proc Natl Acad Sci U S A. 104: 1841-6. PMID: 17264218
3. Susceptibility to breast cancer: hereditary syndromes and low penetrance genes.  |  Nusbaum, R., et al. Breast Dis. 27: 21-50. PMID: 17917139
4. The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells.  |  Ropolo, A., et al. 2007. J Biol Chem. 282: 37124-33. PMID: 17940279
5. Breast cancer risk among male BRCA1 and BRCA2 mutation carriers.  |  Tai, YC., et al. 2007. J Natl Cancer Inst. 99: 1811-4. PMID: 18042939
6. Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma.  |  Arslan, AD., et al. 2017. Oncogene. 36: 6006-6019. PMID: 28671669
7. SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/β-catenin pathway.  |  Wan, G., et al. 2019. Cell Signal. 59: 1-12. PMID: 30844429
8. Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription.  |  Kim, ET., et al. 2021. Nat Microbiol. 6: 234-245. PMID: 33432153
9. SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer.  |  Martinez, RS., et al. 2021. Cancer Res. 81: 3664-3678. PMID: 33985973
10. Comprehensive analysis of bulk and single-cell RNA sequencing data reveals Schlafen-5 (SLFN5) as a novel prognosis and immunity.  |  Wu, YJ., et al. 2024. Int J Med Sci. 21: 2348-2364. PMID: 39310264
11. Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation.  |  Li, J., et al. 2024. Cell Signal. 124: 111468. PMID: 39395526
12. Schlafen, a new family of growth regulatory genes that affect thymocyte development.  |  Schwarz, DA., et al. 1998. Immunity. 9: 657-68. PMID: 9846487

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Slfn5 Antibody (4G2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Slfn5 Antibody (4G2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Slfn5 Antibody (4G2) Specifications

Alternate Product Name: Slfn5

Product Clone Name: 4G2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-338

Epitope Target: Slfn5

Epitope Species: human

Product Reactivity/Detection: Slfn5

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Slfn5 Antibody (4G2): N/A