SLC6A19 Antibody (4F11): sc-293399

SLC6A19 Antibody (4F11) is a mouse monoclonal IgG2a kappa light chain antibody that detects the SLC6A19 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SLC6A19 antibody (4F11) is available as a non-conjugated format. SLC6A19, also known as the sodium-dependent neutral amino acid transporter B(0)AT1, is a 634 amino acid multi-pass membrane protein that plays a crucial role in the transport of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This protein is a member of the sodium:neurotransmitter symporter family and is particularly important for preferentially uptaking leucine in a sodium-dependent manner, which is vital for maintaining amino acid homeostasis in the body. SLC6A19 is predominantly expressed in the skin, kidney, and intestine, with highest concentration found in the renal cortex, proximal tubules, and villus enterocytes. Proper functioning of SLC6A19 is essential, as mutations in the gene encoding this transporter are associated with Hartnup disorder, an autosomal recessive condition that can lead to symptoms such as cerebellar ataxia, psychosis, and skin rashes. The ability of SLC6A19 to facilitate the absorption of large neutral non-aromatic L-amino acids underscores its significance in metabolic processes and nutrient absorption, making SLC6A19 monoclonal antibody (4F11) a valuable tool for researchers studying amino acid transport and related disorders.

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SLC6A19 Antibody (4F11) References:

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