SLC6A19 Activators
The chemical class known as SLC6A19 Activators comprises substances that play a pivotal role in enhancing the activity of the SLC6A19 protein, which is responsible for the absorption of amino acids in the intestine. SLC6A19 is a sodium-dependent amino acid transporter that facilitates the uptake of essential amino acids, such as leucine, phenylalanine, proline, glycine, isoleucine, and valine, from the gut lumen into intestinal cells. These amino acids are crucial for various physiological processes, including protein synthesis and cellular function. SLC6A19 activators can be categorized into two groups: direct substrates and indirect modulators.
Direct substrates of SLC6A19, such as leucine, phenylalanine, proline, glycine, isoleucine, and valine, are transported directly into intestinal cells by SLC6A19, enhancing its activity by providing the necessary amino acids as substrates. These amino acids serve as the building blocks for proteins and play essential roles in cellular metabolism and function. By supplying SLC6A19 with its substrates, these activators ensure the efficient absorption of amino acids in the small intestine, contributing to overall protein homeostasis. Indirect modulators of SLC6A19 include compounds like levofloxacin, ephedrine, pH modifiers (e.g., sodium bicarbonate), mTORC1 activators (e.g., rapamycin), angiotensin II, and insulin. These chemicals indirectly influence SLC6A19 activity through various mechanisms. For example, levofloxacin inhibits competing transporters in the intestine, reducing competition for amino acid absorption. Ephedrine stimulates the sympathetic nervous system, promoting the absorption of amino acids. pH modifiers, such as sodium bicarbonate, create a favorable intestinal environment for amino acid transport. mTORC1 activators like rapamycin support SLC6A19 expression and function through signaling pathways. Angiotensin II and insulin activate intracellular signaling cascades that indirectly enhance SLC6A19, leading to increased amino acid absorption.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $62.00 | ||
Leucine is an amino acid and a direct substrate for SLC6A19, enhancing its activity by being transported. | ||||||
L-Phenylalanine | 63-91-2 | sc-394058 sc-394058A sc-394058B | 100 g 500 g 1 kg | $114.00 $466.00 $693.00 | 1 | |
Phenylalanine, an amino acid, activates SLC6A19 by serving as a direct substrate for transport into cells. | ||||||
L-Proline | 147-85-3 | sc-397196 sc-397196A sc-397196B sc-397196C | 25 g 100 g 1 kg 5 kg | $38.00 $133.00 $208.00 $978.00 | ||
Proline, another amino acid, directly activates SLC6A19 by serving as a substrate for transport into cells. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine is an amino acid that activates SLC6A19 by acting as a direct substrate for transport into cells. | ||||||
L-Isoleucine | 73-32-5 | sc-396706 sc-396706A | 25 g 100 g | $28.00 $120.00 | ||
Isoleucine, an amino acid, directly activates SLC6A19 by serving as a substrate for transport into cells. | ||||||
Levofloxacin | 100986-85-4 | sc-252953 sc-252953B sc-252953A | 10 mg 250 mg 1 g | $40.00 $46.00 $54.00 | 3 | |
Levofloxacin indirectly activates SLC6A19 by inhibiting competing transporters in the intestine. | ||||||
Sodium bicarbonate | 144-55-8 | sc-203271 sc-203271A sc-203271B sc-203271C sc-203271D | 25 g 500 g 1 kg 5 kg 25 kg | $21.00 $29.00 $43.00 $84.00 $697.00 | 1 | |
Modifying intestinal pH with compounds like sodium bicarbonate indirectly impacts SLC6A19 by creating a favorable environment for amino acid transport. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Activation of the mTORC1 signaling pathway indirectly supports SLC6A19 expression, enhancing amino acid absorption. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II indirectly stimulates SLC6A19 through intracellular signaling pathways, promoting amino acid absorption. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates signaling pathways that indirectly enhance SLC6A19 function, increasing amino acid absorption in the intestine. | ||||||