SLC25A46 Antibody (H-5): sc-515810

SLC25A46 Antibody (H-5) is a mouse monoclonal IgA kappa light chain antibody that detects SLC25A46 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SLC25A46 antibody (H-5) is available as a non-conjugated antibody. SLC25A46 protein, also known as solute carrier family 25 member 46, is a crucial 418 amino acid multi-pass membrane protein that plays a significant role in mitochondrial function by facilitating metabolite transport across the inner mitochondrial membrane. This transport maintains cellular energy metabolism and overall mitochondrial health, ensuring proper exchange of substrates necessary for ATP production and other metabolic processes. SLC25A46 is expressed in various tissues and contains two Solcar repeats, localizing specifically to the inner mitochondrial membrane. The human gene encoding SLC25A46 is located on chromosome 5, which is associated with several genetic disorders, including Cockayne syndrome and familial adenomatous polyposis. Understanding SLC25A46 function and interactions within the mitochondrial environment is essential for elucidating its role in cellular metabolism and potential implications in mitochondrial diseases.

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SLC25A46 Antibody (H-5) References:

1. Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register.  |  Kadmon, M., et al. 2001. Int J Colorectal Dis. 16: 63-75. PMID: 11355321
2. The gene for Treacher Collins syndrome maps to the long arm of chromosome 5.  |  Dixon, MJ., et al. 1991. Am J Hum Genet. 49: 17-22. PMID: 1676560
3. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.  |  Haitina, T., et al. 2006. Genomics. 88: 779-790. PMID: 16949250
4. Cockayne syndrome exhibits dysregulation of p21 and other gene products that may be independent of transcription-coupled repair.  |  Cleaver, JE., et al. 2007. Neuroscience. 145: 1300-8. PMID: 17055654
5. A new genomic mechanism leading to cri-du-chat syndrome.  |  South, ST., et al. 2006. Am J Med Genet A. 140: 2714-20. PMID: 17103439
6. Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP).  |  Aretz, S., et al. 2007. Hum Mutat. 28: 985-92. PMID: 17486639
7. Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome.  |  Du, HY., et al. 2007. Aging Cell. 6: 689-97. PMID: 17875000
8. A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization.  |  Saltman, DL., et al. 1993. Genomics. 16: 726-32. PMID: 8325647

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SLC25A46 Antibody (H-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SLC25A46 Antibody (H-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SLC25A46 Antibody (H-5) Specifications

Alternate Product Name: SLC25A46

Product Clone Name: H-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 1-18

Epitope Target: SLC25A46

Epitope Species: human

Product Reactivity/Detection: SLC25A46

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SLC25A46 Antibody (H-5): N/A