SLC13A5 Antibody (2G4): sc-293277

SLC13A5 Antibody (2G4) is a mouse monoclonal IgG1 kappa light chain antibody that detects the SLC13A5 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-SLC13A5 antibody (2G4) is available as the non-conjugated format. SLC13A5, also known as the solute carrier family 13 (sodium-dependent citrate transporter), member 5, is a 568 amino acid multi-pass membrane protein that plays a crucial role in cellular metabolism. SLC13A5 is primarily located in the liver, brain, and testicular tissues, where SLC13A5 functions as a high-affinity sodium/citrate cotransporter, facilitating the electrogenic import of citrate into cells. SLC13A5′s ability to transport citrate is vital for various metabolic processes, including the generation of metabolic energy and the synthesis of cholesterol and fatty acids. Additionally, the gene encoding SLC13A5 is situated on human chromosome 17, a region that is significant not only for its high gene density but also for its association with key tumor suppressor genes such as p53 and BRCA1, which are critical for maintaining genomic stability and preventing cancer. SLC13A5′s interaction with these pathways underscores its importance in both normal physiology and potential disease states, making SLC13A5 a valuable target for research in metabolic disorders and cancer biology.

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SLC13A5 Antibody (2G4) References:

1. Citrate transport by the kidney and intestine.  |  Pajor, AM. 1999. Semin Nephrol. 19: 195-200. PMID: 10192253
2. Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain.  |  Inoue, K., et al. 2002. J Biol Chem. 277: 39469-76. PMID: 12177002
3. Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function.  |  Inoue, K., et al. 2002. Biochem Biophys Res Commun. 299: 465-71. PMID: 12445824
4. Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action.  |  Inoue, K., et al. 2003. Biochem J. 374: 21-6. PMID: 12826022
5. The SLC13 gene family of sodium sulphate/carboxylate cotransporters.  |  Markovich, D. and Murer, H. 2004. Pflugers Arch. 447: 594-602. PMID: 12915942
6. Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters.  |  Pajor, AM. 2006. Pflugers Arch. 451: 597-605. PMID: 16211368
7. Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines.  |  Gopal, E., et al. 2007. Am J Physiol Gastrointest Liver Physiol. 292: G402-8. PMID: 16973915
8. Plasma Membrane Na⁺-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy.  |  Bhutia, YD., et al. 2017. Molecules. 22: PMID: 28264506
9. Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood-brain barrier.  |  Kopel, JJ., et al. 2021. Biochem J. 478: 463-486. PMID: 33544126
10. Molecular Mechanisms of the SLC13A5 Gene Transcription.  |  Li, Z. and Wang, H. 2021. Metabolites. 11: PMID: 34677420
11. The neuroimaging spectrum of SLC13A5 related developmental and epileptic encephalopathy.  |  Whitney, R., et al. 2023. Seizure. 106: 8-13. PMID: 36701889
12. The citrate transporter SLC13A5 as a therapeutic target for kidney disease: evidence from Mendelian randomization to inform drug development.  |  Gill, D., et al. 2023. BMC Med. 21: 504. PMID: 38110950

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SLC13A5 Antibody (2G4) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-SLC13A5 Antibody (2G4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SLC13A5 Antibody (2G4) Specifications

Alternate Product Name: SLC13A5

Product Clone Name: 2G4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 152-206

Epitope Target: SLC13A5

Epitope Species: human

Product Reactivity/Detection: SLC13A5

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for SLC13A5 Antibody (2G4): N/A