Ska3 Antibody (E-10): sc-390910

Ska3 Antibody (E-10) is a mouse monoclonal IgG1 antibody that detects Ska3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Ska3, also known as C13orf3 or RAMA1, is a 412 amino acid protein that plays a critical role in the SKA1 complex, which is essential for proper chromosome segregation during mitosis. The SKA1 complex localizes to the outer kinetochore and spindle microtubules, where Ska3 facilitates the movement of microspheres along microtubules by mediating microtubule-stimulated oligomerization. Ska3′s importance in the SKA1 complex ensures accurate chromosome alignment and separation, which are vital processes for cell division and maintaining genomic stability. The gene encoding Ska3 is located on chromosome 13, a region that harbors several key tumor suppressor genes, including BRCA2 and RB1, both of which are implicated in various cancers. Chromosome 13 integrity is crucial, as abnormalities such as trisomy 13 can lead to severe developmental issues and significantly impact survival rates. With a pivotal role in cell division and potential implications in cancer biology, anti-Ska3 antibody (E-10) serves as an invaluable tool for researchers studying mitotic processes and related pathologies.

The preferred Ska3 antibody is Ska3 Antibody (B-1): sc-390326.