Six3 Antibody (J-21): sc-81985
- Six3 Antibody (J-21) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant Six3 of human origin
- recommended for detection of Six3 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Six3 Antibody (J-21). This work is in progress.
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Six3 Antibody (J-21) is a mouse monoclonal IgG2a antibody that detects Six3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Six3 is a member of the Six family of homeodomain transcription factors, characterized by a conserved DNA binding domain, which plays a crucial role in the development of the eye and brain. Specifically, anti-Six3 antibody (J-21) is essential for studying the specification and proliferation of the eye field in vertebrates, and Six3 expression is critical during early embryonic development, as Six3 is detected in human embryos as early as 5-7 weeks of gestation. Six3 expression is maintained throughout fetal development, particularly in the retina, where Six3 is found in ganglion cells and the inner nuclear layer by 20 weeks of gestation. Importantly, Six3 maps to human chromosome 2p16-p21, a region associated with two dominant disorders, holoprosencephaly type 2 and malattia leventinese, both of which exhibit ocular phenotypes. The identification of Six3 and Six3 interactions with other proteins in the developmental pathways highlights Six3 significance in understanding congenital disorders and potential therapeutic targets. Six3 monoclonal antibody (J-21) is an invaluable tool for researchers investigating the molecular mechanisms underlying eye and brain development.
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Six3 Antibody (J-21) References:
- Down-regulation of SIX3 is associated with clinical outcome in lung adenocarcinoma. | Mo, ML., et al. 2013. PLoS One. 8: e71816. PMID: 23977152
- Six3 regulates optic nerve development via multiple mechanisms. | Samuel, A., et al. 2016. Sci Rep. 6: 20267. PMID: 26822689
- Six3 dosage mediates the pathogenesis of holoprosencephaly. | Geng, X., et al. 2016. Development. 143: 4462-4473. PMID: 27770010
- SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B. | Yu, Z., et al. 2017. J Hematol Oncol. 10: 115. PMID: 28595628
- SIX3 deletions and incomplete penetrance in families affected by holoprosencephaly. | Stokes, B., et al. 2018. Congenit Anom (Kyoto). 58: 29-32. PMID: 28670735
- Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2 Causes Subfertility in Mice via Distinct Mechanisms. | Hoffmann, HM., et al. 2019. Neuroendocrinology. 109: 200-207. PMID: 30261489
- SIX3 and SIX6 interact with GEMININ via C-terminal regions. | Turcu, DC., et al. 2019. Biochem Biophys Rep. 20: 100695. PMID: 31844685
- Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons. | Song, X., et al. 2021. Neurosci Bull. 37: 985-998. PMID: 34014554
- Heterozygous variants in SIX3 and POU1F1 cause pituitary hormone deficiency in mouse and man. | Bando, H., et al. 2023. Hum Mol Genet. 32: 367-385. PMID: 35951005
- Chd5 Regulates the Transcription Factor Six3 to Promote Neuronal Differentiation. | Shrestha, P., et al. 2023. Stem Cells. 41: 242-251. PMID: 36636025
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Six3 Antibody (J-21) | sc-81985 | 100 µg/ml | $333.00 |