Siglec-5/14 Antibody (C-2): sc-374584
- Siglec-5/14 Antibody (C-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 135-173 within an extracellular domain of Siglec-5 of human origin
- recommended for detection of Siglec-5 and Siglec-14 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Siglec-5/14 Antibody (C-2) for WB applications. These reagents are now offered in bundles with Siglec-5/14 Antibody (C-2) (see ordering information below).
Siglec-5/14 Antibody (C-2) is a mouse monoclonal IgG1 antibody that detects Siglec-5 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Siglec-5 is a member of the sialic acid-binding immunoglobulin superfamily and plays a crucial role in immune regulation by recognizing sialylated ligands, which are important for cell-cell interactions and signaling. Siglec-5 is primarily expressed on monocytes and neutrophils, where Siglec-5 contributes to the modulation of immune responses, particularly in the context of inflammation and infection. Notably, Siglec-5 has been implicated in the diagnosis and monitoring of acute myeloid leukemia (AML), as Siglec-5 expression is absent in leukemic cell lines representing early stages of myelomonocytic differentiation. Siglec-5 expression can provide valuable insights into the immune landscape of patients with AML, making anti-Siglec-5 antibody (C-2) an essential tool for researchers studying hematopoietic tissues and related pathologies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Siglec-5/14 Antibody (C-2) | sc-374584 | 200 µg/ml | $322.00 | |||
Siglec-5/14 Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-540481 | 200 µg Ab; 10 µg BP | $361.00 | |||
Siglec-5/14 Antibody (C-2): m-IgG1 BP-HRP Bundle | sc-542151 | 200 µg Ab; 20 µg BP | $361.00 | |||
Siglec-5/14 (C-2) Neutralizing Peptide | sc-374584 P | 100 µg/0.5 ml | $69.00 |