SIGIRR Antibody (D-2): sc-365601

SIGIRR Antibody (D-2) is a mouse monoclonal IgG1 antibody that detects SIGIRR in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SIGIRR, also known as single immunoglobulin domain-containing IL-1 receptor-related protein or Toll/interleukin-1 receptor 8 (TIR8), plays a crucial role as a negative regulator of the interleukin-1 receptor and Toll-like receptor signaling pathways, which are essential for the immune response. By modulating these pathways, SIGIRR helps to prevent excessive inflammation and tissue damage, thereby conferring resistance to infections, such as those caused by Pseudomonas aeruginosa in corneal tissues. SIGIRR is primarily localized in the kidney, lung, and gut, where SIGIRR expression is vital for maintaining immune homeostasis and protecting against pathogenic challenges. Additionally, SIGIRR can form complexes with key signaling molecules, including IL-1 receptor 1, MYD-88, IRAK-1, and TRAF-6, upon stimulation, highlighting SIGIRR′s importance in the regulation of immune responses. With SIGIRR′s ability to interact with these proteins, anti-SIGIRR antibody (D-2) serves as a critical tool for researchers studying immune regulation and related pathologies.

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SIGIRR Antibody (D-2) References:

1. SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.  |  Drexler, SK., et al. 2010. Arthritis Rheum. 62: 2249-61. PMID: 20506350
2. SIGIRR/TIR8, an important regulator of TLR4 and IL-1R-mediated NF-κB activation, predicts biochemical recurrence after prostatectomy in low-grade prostate carcinomas.  |  Bauman, TM., et al. 2015. Hum Pathol. 46: 1744-51. PMID: 26344417
3. SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells.  |  Li, D., et al. 2015. BMC Immunol. 16: 73. PMID: 26634342
4. Ectopic expression of SIGIRR in the colon ameliorates colitis in mice by downregulating TLR4/NF-κB overactivation.  |  Liu, J., et al. 2017. Immunol Lett. 183: 52-61. PMID: 28153604
5. Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro.  |  Tian, F., et al. 2020. J Immunol Res. 2020: 5097920. PMID: 33123603
6. IL-37-induced activation of glycogen synthase kinase 3β promotes IL-1R8/Sigirr phosphorylation, internalization, and degradation in lung epithelial cells.  |  Li, L., et al. 2021. J Cell Physiol. 236: 5676-5685. PMID: 33400290
7. Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis.  |  Yang, X., et al. 2021. Biomed Res Int. 2021: 6683148. PMID: 34036103
8. SIGIRR Downregulation and Interleukin-1 Signaling Intrinsic to Renal Cell Carcinoma.  |  Mantione, ME., et al. 2022. Front Oncol. 12: 894413. PMID: 35814450
9. Regulation of CD18 stability by SIGIRR-modulated ubiquitination: new insights into the relationship between innate immune response and acute lung injury.  |  Tian, F., et al. 2023. FEBS J. 290: 2721-2743. PMID: 36527283
10. SIGIRR gene variants in term newborns with congenital heart defects and necrotizing enterocolitis.  |  Zaikova, EK., et al. 2023. Ann Pediatr Cardiol. 16: 337-344. PMID: 38766461

The preferred SIGIRR antibody is SIGIRR Antibody (A-4): sc-271864.