SHIP-1 Antibody (D-11): sc-514205
- SHIP-1 Antibody (D-11) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 5-27 at the N-terminus of SHIP-1 of mouse origin
- recommended for detection of SHIP-1 p145 of mouse, rat and human origin by WB, IP, IF and ELISA
- See SHIP-1 (P1C1): sc-8425 for SHIP-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SHIP-1 Antibody (D-11) for WB applications. These reagents are now offered in bundles with SHIP-1 Antibody (D-11) (see ordering information below).
SHIP-1 Antibody (D-11) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect SHIP-1, also known as INPP5D, across mouse, rat, and human species. SHIP-1 is an essential SH2-containing inositol phosphatase that plays a critical role in the negative regulation of the PI3K/Akt signaling pathway by dephosphorylating PIP3 to PIP2, thereby modulating key cellular processes such as immune cell activation, proliferation, and survival. This regulation is vital for maintaining immune homeostasis and preventing excessive immune responses that can lead to autoimmune disorders and cancer. SHIP-1 interacts with several important proteins, including the CSF-1 receptor (c-Fms), adaptor proteins like Grb2 and Dok-1, and the p85 subunit of PI3K, facilitating the integration and attenuation of various signaling cascades. SHIP-1 (D-11) monoclonal antibody specifically recognizes an epitope mapping between amino acids 5-27 at the N-terminus of SHIP-1, and is recommended for use in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). By enabling precise detection of SHIP-1 p145, anti-SHIP-1 antibody (D-11) serves as an invaluable tool for researchers investigating signal transduction, hematopoiesis, and immune responses. Understanding the interactions between SHIP-1 and its binding partners is crucial for elucidating its role in regulating cellular functions and its implications in various diseases. SHIP-1 (D-11) antibody provides consistent and accurate results, supporting comprehensive studies of SHIP-1 mediated pathways and interactions within the cellular environment.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SHIP-1 Antibody (D-11) | sc-514205 | 200 µg/ml | $316.00 | |||
SHIP-1 Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-540964 | 200 µg Ab; 10 µg BP | $354.00 | |||
SHIP-1 Antibody (D-11): m-IgG1 BP-HRP Bundle | sc-542495 | 200 µg Ab; 20 µg BP | $354.00 | |||
SHIP-1 (D-11) Neutralizing Peptide | sc-514205 P | 100 µg/0.5 ml | $68.00 |