Sg III Antibody (C-2): sc-271750
- Sg III Antibody (C-2) is a mouse monoclonal IgG1 κ Sg III antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of Sg III of human origin
- Sg III Antibody (C-2) is recommended for detection of Secretogranin III of human origin by WB, IP, IF and ELISA
- Anti-Sg III Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Sg III Antibody (C-2) for WB applications. These reagents are now offered in bundles with Sg III Antibody (C-2) (see ordering information below).
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Sg III Antibody (C-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Sg III protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Sg III antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Sg III protein, also known as secretogranin III, is an acidic glycoprotein that plays a crucial role in storing and releasing neuropeptides and hormones within secretory granules of endocrine and neuroendocrine cells. Secretogranin III localization within these granules is vital for proper regulation of hormone secretion, particularly in response to physiological stimuli. Secretogranin III is predominantly expressed in specific cell types of the anterior lobe of the rat pituitary gland, including mammotropes and thyrotropes, and is involved in processing prohormones into bioactive peptides. Secretogranin III interacts with carboxypeptidase E, a key enzyme in peptide hormone maturation, highlighting secretogranin III importance in endocrine system functionality. High levels of chromogranin A, a family member of secretogranin III, are often associated with neuroendocrine tumors, underscoring secretogranin III relevance in both normal physiology and pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Sg III Antibody (C-2) References:
- Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells. | Hosaka, M., et al. 2002. Mol Biol Cell. 13: 3388-99. PMID: 12388744
- Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands. | Sakai, Y., et al. 2003. J Histochem Cytochem. 51: 227-38. PMID: 12533531
- Immunolocalization of secretogranin II, chromogranin A, and chromogranin B in differentiating human neuroblastoma cells. | Giudici, AM., et al. 1992. Eur J Cell Biol. 58: 383-9. PMID: 1425774
- Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A. | Hosaka, M., et al. 2004. J Biol Chem. 279: 3627-34. PMID: 14597614
- Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules. | Hosaka, M., et al. 2005. J Cell Sci. 118: 4785-95. PMID: 16219686
- Measurements of chromogranin A, chromogranin B (secretogranin I), chromogranin C (secretogranin II) and pancreastatin in plasma and urine from patients with carcinoid tumours and endocrine pancreatic tumours. | Stridsberg, M., et al. 1995. J Endocrinol. 144: 49-59. PMID: 7891024
- Immunohistochemical demonstration of chromogranin A, chromogranin B, and secretogranin II in extra-adrenal paragangliomas. | Schmid, KW., et al. 1994. Mod Pathol. 7: 347-53. PMID: 8058707
- Current status on chromogranin A and pancreastatin. | Robberecht, P., et al. 1993. Acta Gastroenterol Belg. 56: 261-3. PMID: 8266767
- Chromogranin A, secretogranin II and vasoactive intestinal peptide in phaeochromocytomas and ganglioneuromas. | Schmid, KW., et al. 1993. Histopathology. 22: 527-33. PMID: 8354485
- Histamine induces a gene-specific synthesis regulation of secretogranin II but not of chromogranin A and B in chromaffin cells in a calcium-dependent manner. | Bauer, JW., et al. 1993. J Biol Chem. 268: 1586-9. PMID: 8420933
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sg III Antibody (C-2) | sc-271750 | 200 µg/ml | $316.00 | |||
Sg III Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-527285 | 200 µg Ab; 10 µg BP | $354.00 | |||
Sg III Antibody (C-2): m-IgG1 BP-HRP Bundle | sc-532658 | 200 µg Ab; 20 µg BP | $354.00 | |||
Sg III Antibody (C-2) AC | sc-271750 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Sg III Antibody (C-2) HRP | sc-271750 HRP | 200 µg/ml | $316.00 | |||
Sg III Antibody (C-2) FITC | sc-271750 FITC | 200 µg/ml | $330.00 | |||
Sg III Antibody (C-2) PE | sc-271750 PE | 200 µg/ml | $343.00 | |||
Sg III Antibody (C-2) Alexa Fluor® 488 | sc-271750 AF488 | 200 µg/ml | $357.00 | |||
Sg III Antibody (C-2) Alexa Fluor® 546 | sc-271750 AF546 | 200 µg/ml | $357.00 | |||
Sg III Antibody (C-2) Alexa Fluor® 594 | sc-271750 AF594 | 200 µg/ml | $357.00 | |||
Sg III Antibody (C-2) Alexa Fluor® 647 | sc-271750 AF647 | 200 µg/ml | $357.00 | |||
Sg III Antibody (C-2) Alexa Fluor® 680 | sc-271750 AF680 | 200 µg/ml | $357.00 | |||
Sg III Antibody (C-2) Alexa Fluor® 790 | sc-271750 AF790 | 200 µg/ml | $357.00 |