SFRS14 Antibody (S-24): sc-101131
- SFRS14 Antibody (S-24) is a mouse monoclonal IgG2a κ SFRS14 antibody provided at 50 µg/500 µl
- raised against recombinant SFRS14 of human origin
- recommended for detection of SFRS14 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SFRS14 Antibody (S-24). This work is in progress.
QUICK LINKS
SFRS14 Antibody (S-24) is a mouse monoclonal IgG2a kappa light chain antibody that detects SFRS14 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-SFRS14 antibody (S-24) is available as a non-conjugated format. SFRS14, also known as splicing factor, arginine/serine-rich 14, is a 1,082 amino acid protein that plays a crucial role in regulating pre-mRNA splicing, a fundamental process in gene expression. SFRS14 features a unique structure, including an arginine/serine-rich region at the N-terminus, two SURP motif repeats, and a C-terminal G-patch domain. The SURP motif is commonly associated with splicing proteins, while the G-patch domain indicates RNA-binding proteins in eukaryotes, highlighting SFRS14′s involvement in RNA processing. SFRS14 shows predominant expression in fetal brain, fetal kidney, and adult testis, and localizes to the nucleus where SFRS14 facilitates pre-mRNA splicing. SFRS14 contains several potential phosphorylation sites, suggesting function modulation through post-translational modifications that influence activity and protein interactions. Three isoforms of SFRS14 exist due to alternative splicing events, further underscoring the complexity and regulatory potential in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SFRS14 Antibody (S-24) References:
- SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. | Sampson, ND. and Hewitt, JE. 2003. Gene. 305: 91-100. PMID: 12594045
- Cloning and characterization of a novel endoplasmic reticulum localized G-patch domain protein, IER3IP1. | Yiu, WH., et al. 2004. Gene. 337: 37-44. PMID: 15276200
- Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP. | Kuwasako, K., et al. 2006. Structure. 14: 1677-89. PMID: 17098193
- Microarray analysis of homocysteine-responsive genes in cardiac neural crest cells in vitro. | Rosenquist, TH., et al. 2007. Dev Dyn. 236: 1044-54. PMID: 17326132
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. | Nagase, T., et al. 1997. DNA Res. 4: 141-50. PMID: 9205841
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SFRS14 Antibody (S-24) | sc-101131 | 50 µg/500 µl | $339.00 |